ArticleBrain and behavior2022
Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- Head injury/traumatic brain injury and the risk of dementia: An observational and Mendelian randomization study.The journal of prevention of Alzheimer's disease · 2026Observational
- Longitudinal changes in cognitive ability following traumatic brain injury: a systematic review and meta-analysis.Brain communications · 2026Review
- Dynamic changes in neuron-specific enolase level to glasgow coma scale score ratio predict long-term neurological function of diffuse axonal injury patients.BMC neurology · 2025Observational
- Brain tissue integrity in neuromyelitis optica spectrum disorder through T1-w/T2-w ratio, MTR and DTI.Journal of neurology · 2025Article
- History of traumatic brain injury does not alter course of neurocognitive decline in older adults with and without cognitive impairment.Neuropsychology · 2023Article
- The Relationship Between Cortical Morphological and Functional Topological Properties and Clinical Manifestations in Patients with Posttraumatic Diffuse Axonal Injury: An Individual Brain Network Study.Brain topography · 2023Article
- Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury.BMC neurology · 2023Article
- Cognitive impairment in diffuse axonal injury patients with favorable outcome.Frontiers in neuroscience · 2023Article
- Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury.Brain and behavior · 2022Article
- The ratio of serum neuron-specific enolase level to admission glasgow coma scale score is associated with diffuse axonal injury in patients with moderate to severe traumatic brain injury.Frontiers in neurology · 2022Article
- Structural Myelin Mapping in Individuals with a History of Head Injury.Neurotrauma reportsArticle
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Authors and funding
10 authors.
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Abstract
backgroundDiffuse axonal injury (DAI) is a frequent mechanism of traumatic brain injury (TBI) that triggers a sequence of parenchymal changes that progresses from focal axonal shear injuries up to inflammatory response and delayed axonal disconnection.
objectiveThe main purpose of this study is to evaluate changes in the axonal/myelinic content and the brain volume up to 12 months after TBI and to correlate these changes with neuropsychological results.
methodsPatients with DAI (n = 25) were scanned at three time points after trauma (2, 6, and 12 months), and the total brain volume (TBV), gray matter volume, and white matter volume (WMV) were calculated in each time point. The magnetization transfer ratio (MTR) for the total brain (TB MTR), gray matter (GM MTR), and white matter (WM MTR) was also quantified. In addition, Hopkins verbal learning test (HVLT), Trail Making Test (TMT), and Rey-Osterrieth Complex Figure test were performed at 6 and 12 months after the trauma.
resultsThere was a significant reduction in the mean TBV, WMV, TB MTR, GM MTR, and WM MTR between time points 1 and 3 (p < .05). There was also a significant difference in HVLT-immediate, TMT-A, and TMT-B scores between time points 2 and 3. The MTR decline correlated more with the cognitive dysfunction than the volume reduction.
conclusionA progressive axonal/myelinic rarefaction and volume loss were characterized, especially in the white matter (WM) up to 1 year after the trauma. Despite that, specific neuropsychological tests revealed that patients' episodic verbal memory, attention, and executive function improved during the study. The current findings may be valuable in developing long-term TBI rehabilitation management programs.
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