Evidence map›Paper›PMID 35103387›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study.

Cheng Chen, Eric A Whitsel, Mark A Espeland, Linda Snetselaar, Kathleen M Hayden, Archana P Lamichhane, Marc L Serre, William Vizuete, Joel D Kaufman, Xinhui Wang and 4 more

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Cheng ChenDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, Department of Medicine, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
Mark A EspelandDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Linda SnetselaarDepartment of Epidemiology, College of Public Health, the University of Iowa, Iowa City, Iowa, USA.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Archana P LamichhaneDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Marc L SerreDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
William VizueteDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, Department of Medicine, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Xinhui WangDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Helena C ChuiDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Mary E D'AltonDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Jiu-Chiuan ChenDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Ka KaheDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID 0000-0001-5078-2010
University of North Carolina at Chapel Hill · USColumbia University · USUniversity of Southern California · USWake Forest University · USUniversity of Iowa · USUniversity of Washington · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW · 2016 to 2020
$12.2M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, FINCH, CALEB E · 2018 to 2022
$11.5M
Alzheimer's Disease & Related Dementias: Geography, Environments, and MechanismsRF1AG054068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2016 to 2016
$4.1M
Environmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2M
Residential Radon Exposure and Stroke Risk: the REGARDS StudyR01NS122449 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KAHE, KA, SMITH, BRIAN JOSEPH · 2021 to 2025
$3.1M
Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
Environmental Determinants of Cognitive Aging in the WHI Memory StudyR01AG033078 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2011 to 2014
$2.6M
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS P01 AG055367NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG033078NIA NIH HHS R21 AG054955NIA NIH HHS RF1 AG054068NIA NIH HHS RF1 AG056111NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES025888NINDS NIH HHS R01 NS122449
6 · The paper itself

Abstract

introductionParticulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B

methodsThis study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by food frequency questionnaires at baseline. The 3-year average PM

resultsDuring a mean follow-up of 9 years, 342 participants developed all-cause dementia. We found that residing in locations with PM DISCUSSION: This is the first study suggesting that the putative neurotoxicity of PM

Indexed as

DementiaVitamin B ComplexFemaleFolic AcidHumansIncidenceParticulate MatterVitamin B 12Women's HealthFolic AcidParticulate MatterVitamin B 12Vitamin B Complexdementiafine particulate matterfolatePM2.5vitamin B12vitamin B6

Identifiers

PMID35103387
PMCPMC9339592
OpenAlexW4210347978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.