Evidence map›Paper›PMID 35103385›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

The role of nativity in heterogeneous dementia incidence in a large cohort of three Asian American groups and white older adults in California.

Eleanor Hayes-Larson, Joseph Fong, Taylor M Mobley, Paola Gilsanz, Rachel A Whitmer, Gilbert C Gee, Ron Brookmeyer, Elizabeth Rose Mayeda

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011-2019.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  4. Article
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  7. Article
  8. Correlation between theFrontiers in public health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Eleanor Hayes-LarsonDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Joseph FongDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Taylor M MobleyDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Paola GilsanzDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Rachel A WhitmerAlzheimer's Disease Center, University of California, Davis, Sacramento, California, USA.
Gilbert C GeeDepartment of Community Health Sciences, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Ron BrookmeyerDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
UCLA Health · USUniversity of California, Davis · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Lifecourse health, cerebral pathology and ethnic disparities in dementiaRF1AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GLYMOUR, MEDELLENA MARIA · 2016 to 2016
$13.1M
Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
Alzheimer’s disease and related dementias in a diverse cohort of Asian AmericansR01AG063969 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYEDA, ELIZABETH ROSE · 2019 to 2022
$2.0M
Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular ComplicationsR01AG067199 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2020 to 2024
$1.9M
NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG063969NIA NIH HHS R01 AG067199NIA NIH HHS RF1 AG052132NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

introductionLiterature shows lower dementia incidence in Asian American groups versus whites, varying by Asian ethnicity. One hypothesized driver is nativity differences (eg, healthy immigrant effect).

methodsWe followed a cohort of 6243 Chinese, 4879 Filipino, 3256 Japanese, and 141,158 white Kaiser Permanente Northern California members for incident dementia (2002 to 2020), estimating age-adjusted dementia incidence rates by ethnicity and nativity, and hazard ratios (HR) for nativity on dementia incidence using ethnicity-stratified age- and sex-adjusted Cox proportional hazards models.

resultsDementia incidence appeared higher in foreign- versus US-born Filipinos (HR, 95% confidence interval: 1.39, 1.02 to 1.89); differences were small in Japanese (1.07, 0.88 to 1.30) and Chinese (1.07, 0.92 to 1.24). No nativity differences were observed among whites (1.00, 0.95 to 1.04). DISCUSSION: Nativity does not explain lower dementia incidence in Asian Americans versus whites, but may contribute to heterogeneity across Asian ethnicities. Future research should explore differential impacts of social and cardiometabolic factors.

Indexed as

AsianWhite PeopleAgedCaliforniaChinaDementiaHumansIncidenceJapanPhilippinesdementiaincidencenativityracial/ethnic disparities

Identifiers

PMID35103385
PMCPMC9339576
OpenAlexW4210555108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.