Evidence map›Paper›PMID 35103217›Full record

ArticleCureus2022

Voriconazole-Induced Cholestatic Hepatotoxicity in an Immune Competent Patient.

Yaser Mohammed, Ahmed Abousamra, Ahmed Atef I Abdeldayem, Mansoor Zafar, Tila Muhammad

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yaser MohammedInternal Medicine, Conquest Hospital, East Sussex Healthcare NHS Trust, St Leonards-on-Sea, GBR.
Ahmed AbousamraInternal Medicine, Conquest Hospital, East Sussex Healthcare NHS Trust, St Leonards-on-Sea, GBR.
Ahmed Atef I AbdeldayemIntensive Care Unit, Conquest Hospital, East Sussex Healthcare NHS Trust, St Leonards-on-Sea, GBR.
Mansoor ZafarGastroenterology and Hepatology, Conquest Hospital, East Sussex Healthcare NHS Trust, St Leonards-on-Sea, GBR.
Tila MuhammadGastroenterology and Hepatology, Conquest Hospital, East Sussex Healthcare NHS Trust, St Leonards-on-Sea, GBR.
Conquest Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voriconazole is a frequently prescribed anti-fungal medication used in particular for invasive aspergillosis. Voriconazole-induced hepatotoxicity is a relatively rare but serious clinicopathologic entity. We report a patient presenting with impaired liver function test results pointing towards the cholestatic picture. The patient had initial blood tests to confirm cholestasis, followed by imaging modalities that did not show any obstruction along the common bile duct and/or pancreatic pathway. The patient's voriconazole dose reduction was advised, resulting in lower levels of abnormal liver function tests.

Indexed as

cholestatic liver injuryderanged liver function testsdose titrationinvasive aspergillosisvoriconazole toxicity

Identifiers

PMID35103217
PMCPMC8769073
OpenAlexW4206552728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.