ArticleCureus2021
A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers.
Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Nutritional supplements to improve esports player performance: a systematic review of randomized controlled trials.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Effects of nutritional interventions on competitive performance and dose‒response relationships among esports players of different skill levels: a systematic review and three-level meta-analysis.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Health Consequences of Intensive E-Gaming: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Theacrine as a novel ergogenic aid: impact on canoe sprint performance.Journal of the International Society of Sports Nutrition · 2025Trial
- Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women.Nutrients · 2023Trial
- Dose response effects of theacrine on cognitive performance and subsequent sleep.Scientific reports · 2024Article
- Caffeine improves the shooting performance and reaction time of first-person shooter esports players: a dose-response study.Frontiers in sports and active living · 2024Article
- Article
- Nutrition, lifestyle, and cognitive performance in esport athletes.Frontiers in nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Involvement in video game activities and competitive video gaming (esports) is a rapidly growing field. Moreover, there is a marked interest in identifying nutritional supplements to safely improve egamer performance. Methodology We conducted a repeated-measure, randomized crossover study to compare the effects of caffeine (125 mg), caffeine (125 mg) + Dynamine® (75 mg) + TeaCrine® (50 mg) (CDT), and matched placebo across three testing sessions (one week apart) among 50 young male egamers. We tested the effect of each product on multiple measures of cognition, self-reported mood (anxiety, alertness, and headache), and biomarkers of arousal (cortisol and salivary alpha-amylase). We also measured electroencephalogram power during the cognitive tasks. Finally, we tested whether individual differences in xenobiotic metabolism would affect the study outcome measures by genotyping each participant for
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.