Evidence map›Paper›PMID 35103095›Full record

ReviewOxidative medicine and cellular longevity2022

Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy.

Zhaobing Tang, Peng Wang, Chao Dong, Juan Zhang, Xiong Wang, Haifeng Pei

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhaobing TangDepartment of Rehabilitation Medicine, The General Hospital of Western Theater Command, Chengdu 610083, China.ORCID https://orcid.org/0000-0002-6115-8093
Peng WangDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Chao DongDepartment of Rehabilitation Medicine, The General Hospital of Western Theater Command, Chengdu 610083, China.
Juan ZhangEmei Rehabilitation and Sanatorium Center of PLA, Leshan 614201, China.
Xiong WangDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.ORCID https://orcid.org/0000-0002-2426-4284
Haifeng PeiDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.ORCID https://orcid.org/0000-0003-1502-8404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DCM are left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function. DCM will lead to cardiac dysfunction, eventually progress to cardiac arrhythmia, heart failure, and sudden cardiac death. At present, the pathogenesis of DCM is complex and not fully elucidated, and oxidative stress (OS), inflammatory response, glucolipid metabolism disorder, etc., are considered as the potential pathophysiological mechanisms. As a consequence, there is no specific and effective treatment for DCM. OS refers to the imbalance between reactive oxygen species (ROS) accumulation and scavenging, oxidation, and antioxidants in vivo, which is widely studied in DCM. Numerous studies have pointed out that regulating the OS signaling pathways and reducing the generation and accumulation of ROS are potential directions for the treatment of DCM. This review summarizes the major OS signaling pathways that are related to the pathogenesis of DCM, providing ideas about further research and therapy.

Indexed as

Signal TransductionDiabetes ComplicationsDiabetic CardiomyopathiesHumansNF-kappa BOxidative StressReactive Oxygen SpeciesSirtuin 1NF-kappa BReactive Oxygen SpeciesSirtuin 1

Identifiers

PMID35103095
PMCPMC8800599
OpenAlexW4207073245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.