Evidence map›Paper›PMID 35102894›Full record

ArticleActa crystallographica. Section F, Structural biology communications2022

Crystal structure of a hypothetical protein from Giardia lamblia.

Dylan K Beard, Seonna Bristol, Kayla Cosby, Amber Davis, Courtney Manning, Lionel Perry, Lauren Snapp, Arian Toy, Kayla Wheeler, Jeremy Young and 7 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Crystal structures of the putative endoribonuclease L-PSP from Entamoeba histolytica.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  3. The roles of COX-2 in protozoan infection.Frontiers in immunology · 2023
    Review
  4. Crystal structure of a hypothetical protein from Giardia lamblia. Corrigendum.Acta crystallographica. Section F, Structural biology communications · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Dylan K BeardDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Seonna BristolDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Kayla CosbyDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Amber DavisDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Courtney ManningDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Lionel PerryDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Lauren SnappDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Arian ToyDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.ORCID 0000-0003-3796-3102
Kayla WheelerDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Jeremy YoungDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Bart StakerSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
Tracy L ArakakiLabcorp Drug Development Inc., Princeton, NJ 08540, USA.
Jan AbendrothSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.ORCID 0000-0002-8229-3243
Sandhya SubrahamanianSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
Thomas E EdwardsSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.ORCID 0000-0002-0474-8003
Peter J MylerCenter for Infectious Disease Research, formerly Seattle Biomedical Research Institute, 307 Westlake Avenue North Suite 500, Seattle, WA 98109, USA.ORCID 0000-0002-0056-0513
Oluwatoyin A AsojoDepartment of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.ORCID 0000-0002-4043-2700
Hampton University · USCenter for Infectious Disease Research · USLabCorp (United States) · US

Funding

HU-CHEM: Deploying evidence-based interventions in Chemistry at Hampton University to plug leaks in the biomedical training pipelineU01GM138433 · NIGMS · HAMPTON UNIVERSITY · PI ASOJO, OLUWATOYIN AJIBOLA · 2020 to 2022
$1.1M
NIAID NIH HHS HHSN272200700057CNIAID NIH HHS HHSN272201200025CNIAID NIH HHS HHSN272201700059CNIGMS NIH HHS 1U01GM138433-01NIGMS NIH HHS U01 GM138433
6 · The paper itself

Abstract

Giardiasis is the most prevalent diarrheal disease globally and affects humans and animals. It is a significant problem in developing countries, the number one cause of travelers' diarrhea and affects children and immunocompromised individuals, especially HIV-infected individuals. Giardiasis is treated with antibiotics (tinidazole and metronidazole) that are also used for other infections such as trichomoniasis. The ongoing search for new therapeutics for giardiasis includes characterizing the structure and function of proteins from the causative protozoan Giardia lamblia. These proteins include hypothetical proteins that share 30% sequence identity or less with proteins of known structure. Here, the atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement. The structure has the two-layer αβ-sandwich topology observed in the prototypical endoribonucleases L-PSPs (liver perchloric acid-soluble proteins) with conserved allosteric active sites containing small molecules from the crystallization solution. This article is an educational collaboration between Hampton University and the Seattle Structural Genomics Center for Infectious Disease.

Indexed as

Catalytic DomainCrystallography, X-RayGiardia lambliaModels, MolecularProtein ConformationProtozoan ProteinsProtozoan Proteinsgiardiasisinfectious diseasesSSGCIDstructural genomicstravelers' diarrheaundergraduate education and training

Identifiers

PMID35102894
PMCPMC8805217
OpenAlexW4210262049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.