Evidence map›Paper›PMID 35102766›Full record

ArticleJournal of attention disorders2022

Heritability and Clinical Characteristics of Neuropsychological Profiles in Youth With and Without Elevated ADHD Symptoms.

Anne B Arnett, Lauren M McGrath, Brian P Flaherty, Bruce F Pennington, Erik G Willcutt

Abstract readHistorical Article
In one paragraph

Article in Journal of attention disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. The role of single trial variability in event related potentials in children with attention deficit hyperactivity disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne B ArnettBoston Children's Hospital, Brookline, MA, USA.ORCID 0000-0003-1342-0488
Lauren M McGrathUniversity of Denver, CO, USA.
Brian P FlahertyUniversity of Washington, Seattle, USA.
Bruce F PenningtonUniversity of Denver, CO, USA.
Erik G WillcuttUniversity of Colorado at Boulder, USA.

Funding

VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Neurophysiologically Defined Subtypes of ADHDR00MH116064 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI ARNETT, ANNE BERNARD · 2021 to 2023
$884k
Cognitive and neural predictors of comorbidity between reading and attention problemsR15HD086662 · NICHD · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI MCGRATH, LAUREN M · 2016 to 2016
$410k
Neurophysiologically Defined Subtypes of ADHDK99MH116064 · NIMH · UNIVERSITY OF WASHINGTON · PI ARNETT, ANNE BERNARD · 2018 to 2019
$255k
NICHD NIH HHS P50 HD027802NICHD NIH HHS P50 HD105351NICHD NIH HHS R15 HD086662NIMH NIH HHS K99 MH116064NIMH NIH HHS R00 MH116064
6 · The paper itself

Abstract

objectiveIn the last decade, there has been an increase in research that aims to parse heterogeneity in attention deficit hyperactivity disorder (ADHD). The current study tests heritability of latent class neuropsychological subtypes.

methodLatent class analysis was used to derive subtypes in a sample of school-age twins (

resultsFive neuropsychological profiles replicated across twin 1 and twin 2 datasets. Latent class membership was heritable overall, but heritability varied by profile and was lower than heritability of ADHD status. Variability in neuropsychological performance across domains was the strongest predictor of elevated ADHD symptoms. Neuropsychological profiles showed distinct associations with age, psychiatric symptoms and reading ability.

conclusionNeuropsychological profiles are associated with unique neurocognitive presentations, but are not strong candidate endophenotypes for ADHD diagnosis.

Indexed as

Attention Deficit Disorder with HyperactivityAdolescentCognitionHumansTwinsADHDbehavioral geneticsheritabilitylatent class analysisneuropsychological

Identifiers

PMID35102766
PMCPMC9283222

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.