Evidence map›Paper›PMID 35102732›Full record

Trial reportEuropean journal of physical and rehabilitation medicine2022

Stimulation of both inspiratory and expiratory muscles versus diaphragm-only paradigm for rehabilitation in severe chronic obstructive pulmonary disease patients: a randomized controlled pilot study.

Zhiling Zhao, Wuzhuang Sun, Xiaoyun Zhao, Xiaojuan Wang, Yingxiang Lin, Shu Zhang, Zhu Li, Yong Lu, Juanni Gong, Yanxia Yu and 4 more

Open access · diamondAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of physical and rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Zhiling ZhaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wuzhuang SunDepartment of Respiratory Medicine and PCCM, The First Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China.
Xiaoyun ZhaoDepartment of Pulmonary and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.
Xiaojuan WangDepartment of General Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yingxiang LinDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Shu ZhangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Zhu LiDepartment of Respiratory Medicine and PCCM, The First Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China.
Yong LuDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Juanni GongDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Yanxia YuDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Bojun LiDepartment of Pulmonary and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.
Xiujuan HuDepartment of Pulmonary and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.
Yuechuan LiDepartment of Pulmonary and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China.
Zhaohui TongDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China - tongzhaohuicy@sina.com.
Beijing Chao-Yang Hospital · CNTianjin Chest Hospital · CNCapital Medical University · CNFirst Affiliated Hospital of Hebei Medical University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD), a progressive lung disease, might improve with neuromuscular electrical stimulation. No trials on inspiratory plus expiratory neuromuscular electrical stimulation have been conducted yet.

aimThe aim of this study was to evaluate the safety and effectiveness of inspiratory plus expiratory neuromuscular electrical stimulation in subjects with severe COPD.

designThis was a multicenter, prospective, randomized controlled trial.

settingThe subjects were outpatients enrolled from Beijing Chao-Yang Hospital affiliated with Capital Medical University, Tianjin Chest Hospital, and the First Hospital of Hebei Medical University. POPULATION: Subjects had stable COPD with severe respiratory impairment.

methodsUsing a computer statistical software, 120 stable subjects were randomly allocated (1:1) to receive inspiratory plus expiratory neuromuscular electrical stimulation (study group) and diaphragm pacing (control group). Demographic and clinical data were collected before, and after 2, and 4 weeks of the trial. The intention-to-treat analysis was conducted. The primary outcome was to analyze the changes in functional exercise capacity, estimated as six-minute walk distance (6MWD), following electrical stimulation for 4 weeks. The secondary outcomes were changes in modified Medical Research Council score, forced expiratory volume in 1 second (FEV<inf>1</inf>), FEV<inf>1</inf>% predicted, and FEV<inf>1</inf> ratio forced vital capacity (FEV<inf>1</inf>/FVC) following electrical stimulation for 4 weeks.

resultsThe change in 6MWD was greater in the study group (65.53±39.45 m) than in the control group (26.66±32.65 m). The mean between-group difference at the fourth week was 29.07 m (95% confidence interval, 16.098-42.035; P<0.001). There were no significant between-group differences in the secondary outcomes after 4 weeks of electrical stimulation. For GOLD-4 COPD subjects, FEV<inf>1</inf> and FEV<inf>1</inf>/FVC improved in the study group (P<0.05). No electrical stimulation-related serious adverse events were observed in either group.

conclusions6MWD were increased significantly, without adverse events, after four weeks of treatment of inspiratory plus expiratory neuromuscular electrical stimulation in stable patients with severe COPD, suggesting that this protocol benefits COPD rehabilitation. CLINICAL REHABILITATION IMPACT: The results of this study suggest that the simultaneous use of inspiratory plus expiratory neuromuscular electrical stimulation as an adjunct therapy may improve the functional exercise capacity of severe stable COPD subjects.

Indexed as

DiaphragmPulmonary Disease, Chronic ObstructiveForced Expiratory VolumeHumansPilot ProjectsProspective Studies

Identifiers

PMID35102732
PMCPMC9980572
OpenAlexW4210705241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.