ArticleJournal of biomedical optics2022
Fluid mechanics approach to analyzing collagen fiber organization.
Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Segmentation-free Radon transform algorithm to detect orientation and size of tissue structures in multiphoton microscopy images.Journal of biomedical optics · 2025Article
- Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
significanceThe spatial organization of collagen fibers has been used as a biomarker for assessing injury and disease progression. However, quantifying this organization for complex structures is challenging.
aimTo quantify and classify complex collagen fiber organizations. APPROACH: Using quantitative second-harmonic generation (SHG) microscopy, we show that collagen-fiber orientation can be viewed as pseudovector fields. Subsequently, we analyze them using fluid mechanic metrics, such as energy U, enstrophy E, and tortuosity τ.
resultsWe show that metrics used in fluid mechanics for analyzing fluid flow can be adapted to analyze complex collagen fiber organization. As examples, we consider SHG images of collagenous tissue for straight, wavy, and circular fiber structures.
conclusionsThe results of this study show the utility of the chosen metrics to distinguish diverse and complex collagen organizations. We find that the distribution of values for E and U increases with collagen fiber disorganization, where they divide between low and high values corresponding to uniformly aligned fibers and disorganized collagen fibers, respectively. We also confirm that the values of τ cluster around 1 when the fibers are straight, and the range increases up to 1.5 when wavier fibers are present.
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