ArticleJournal of thrombosis and haemostasis : JTH2022
Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors.
Article in Journal of thrombosis and haemostasis : JTH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial.Nature medicine · 2025Trial
- Nanopore-based metagenomics analysis reveals microbial presence in amniotic fluid: A prospective study.Heliyon · 2024Article
- Heterogeneity of platelets and their responses.Research and practice in thrombosis and haemostasis · 2024Article
- Article
- Application of the thrombin generation assay in patients with antiphospholipid syndrome: A systematic review of the literature.Frontiers in cardiovascular medicine · 2023Review
- Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors.Journal of thrombosis and haemostasis : JTH · 2022Article
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Authors and funding
25 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeographic variability in coagulation across populations and their determinants are poorly understood.
objectiveTo compare thrombin (TG) and plasmin (PG) generation parameters between healthy Tanzanian and Dutch individuals, and to study associations with inflammation and different genetic, host and environmental factors.
methodsTG and PG parameters were measured in 313 Tanzanians of African descent living in Tanzania and 392 Dutch of European descent living in the Netherlands and related to results of a dietary questionnaire, circulating inflammatory markers, genotyping, and plasma metabolomics.
resultsTanzanians exhibited an enhanced TG and PG capacity, compared to Dutch participants. A higher proportion of Tanzanians had a TG value in the upper quartile with a PG value in the lower/middle quartile, suggesting a relative pro-coagulant state. Tanzanians also displayed an increased normalized thrombomodulin sensitivity ratio, suggesting reduced sensitivity to protein C. In Tanzanians, PG parameters (lag time and TTP) were associated with seasonality and food-derived plasma metabolites. The Tanzanians had higher concentrations of pro-inflammatory cytokines, which correlated strongly with TG and PG parameters. There was limited overlap in genetic variation associated with TG and PG parameters between the two cohorts. Pathway analysis of genetic variants in the Tanzanian cohort revealed multiple immune pathways that were enriched with TG and PG traits, confirming the importance of co-regulation between coagulation and inflammation.
conclusionsTanzanians have an enhanced TG and PG potential compared to Dutch individuals, which may relate to differences in inflammation, genetics and diet. These observations highlight the importance of better understanding of the geographic variability in coagulation across populations.
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