Evidence map›Paper›PMID 35102560›Full record

ReviewAllergy2022

Cannabis-related allergies: An international overview and consensus recommendations.

Isabel J Skypala, Samira Jeimy, Hannelore Brucker, Ajay P Nayak, Ine I Decuyper, Jonathan A Bernstein, Lori Connors, Amin Kanani, Ludger Klimek, Shun Chi Ryan Lo and 11 more

Open access · bronzeAbstract readReviewConsensus Statement
In one paragraph

Review in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. IgE-mediated lipid transfer protein allergy in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Imported allergens in Italy: an emerging issue.Italian journal of pediatrics · 2024
    Review
  12. Feast for thought: A comprehensive review of food allergy 2021-2023.The Journal of allergy and clinical immunology · 2024
    Review
  13. Review
  14. Relevance of lipid transfer protein to Cannabis sensitization in North America.The journal of allergy and clinical immunology. In practice · 2023
    Article
  15. Article
  16. Article
  17. The Emerging Spectrum of Respiratory Diseases in the U.S. Cannabis Industry.Seminars in respiratory and critical care medicine · 2023
    Article
  18. A review of cannabis allergy in the early days of legalization.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 6 countries.

Isabel J SkypalaDepartment of Allergy & Clinical Immunology, Royal Brompton & Harefield Hospitals, and Imperial College, London, UK.ORCID 0000-0003-3629-4293
Samira JeimyDivision of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Ontario, Canada.ORCID 0000-0002-3425-1874
Hannelore BruckerSouthdale Allergy and Asthma Clinic, Minneapolis, Minnesota, USA.ORCID 0000-0003-3039-7742
Ajay P NayakCenter for Translational Medicine and Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3437-0096
Ine I DecuyperDepartment of Pediatrics, Faculty of Medicine and Health Sciences, University Hospital of Antwerp, University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-8127-5791
Jonathan A BernsteinDivision of Immunology/Allergy Section, Department of Internal Medicine, University of Cincinnati College of Medicine and Bernstein Allergy Group; Bernstein Clinical Research Center, Cincinnati, Ohio, USA.ORCID 0000-0002-3476-1196
Lori ConnorsDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-6777-2174
Amin KananiDivision of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-2081-9318
Ludger KlimekCenter for Rhinology and Allergy, Wiesbaden, Germany.ORCID 0000-0002-2455-0192
Shun Chi Ryan LoDivision of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-6247-7379
Kevin R MurphyDivision of Allergy, Asthma and Pediatric Pulmonology, Department of Pediatrics, Boys Town National Research Hospital, Omaha, Nebraska, USA.
Anil NandaAsthma and Allergy Center, Lewisville and Flower Mound, Dallas, Texas, USA.ORCID 0000-0002-0392-0553
Jill A PooleDivision of Allergy and Immunology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-6236-2563
Jolanta Walusiak-SkorupaDepartment of Occupational Medicine and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland.ORCID 0000-0003-0836-6800
Gordon SussmanDepartment of Medicine and Division of Clinical Immunology & Allergy, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-2202-2513
Joanna S ZeigerCanna Research Foundation, Boulder, Colorado, USA.ORCID 0000-0002-2421-2206
Richard E GoodmanFood Allergy Research and Resource Program, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0001-8243-2285
Anne K EllisDivision of Allergy & Immunology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-0725-2353
William S SilversDivision of Allergy Clinical Immunology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5547-6992
Didier G EboFaculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-0672-7529
International Cannabis Allergy Collaboration
University of Antwerp · BEUniversity of British Columbia · CAAsthma and Allergy Specialists · USAtlanta Allergy and Asthma Clinic · USBernstein Clinical Research Center · USBlue Canyon Technologies (United States) · USBoys Town National Research Hospital · USDalhousie University · CAHarefield Hospital · GBNofer Institute of Occupational Medicine · PLQueen's University · CAThomas Jefferson University · USUniversity of Colorado Denver · USUniversity of Nebraska–Lincoln · USUniversity of Nebraska Medical Center · USUniversity of Toronto · CAWestern University · CAZentrum für Rhinologie und Allergologie · DE

Funding

Allergic sensitization to Cannabis: Innovative diagnostic approachesR21AI140411 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI NAYAK, AJAY · 2019 to 2020
$429k
NIAID NIH HHS R21 AI140411
6 · The paper itself

Abstract

Cannabis is the most widely used recreational drug in the world. Cannabis sativa and Cannabis indica have been selectively bred to develop their psychoactive properties. The increasing use in many countries has been accelerated by the COVID-19 pandemic. Cannabis can provoke both type 1 and type 4 allergic reactions. Officially recognized allergens include a pathogenesis-related class 10 allergen, profilin, and a nonspecific lipid transfer protein. Other allergens may also be relevant, and recognition of allergens may vary between countries and continents. Cannabis also has the potential to provoke allergic cross-reactions to plant foods. Since cannabis is an illegal substance in many countries, research has been hampered, leading to challenges in diagnosis since no commercial extracts are available for testing. Even in countries such as Canada, where cannabis is legalized, diagnosis may rely solely on the purchase of cannabis for prick-to-prick skin tests. Management consists of avoidance, with legal issues hindering the development of other treatments such as immunotherapy. Education of healthcare professionals is similarly lacking. This review aimed to summarize the current status of cannabis allergy and proposes recommendations for the future management of this global issue.

Indexed as

CannabisCOVID-19Food HypersensitivityHypersensitivityAllergensAntigens, PlantHumansImmunoglobulin EPandemicsSkin TestsAllergensAntigens, PlantImmunoglobulin Eallergy diagnosisallergy treamentcannabis allergyIgEoccupational allergies

Identifiers

PMID35102560
PMCPMC9871863
OpenAlexW4210245035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.