Evidence map›Paper›PMID 35102482›Full record

ArticleJournal of general internal medicine2022

Presence of Geriatric Conditions Is Prognostic of Major Bleeding in Older Patients with Atrial Fibrillation: a Cohort Study.

Weijia Wang, Jane S Saczynski, Darleen Lessard, Robert J Goldberg, David Parish, Robert Helm, Catarina I Kiefe, Katherine Trymbulak, Jordy Mehawej, Hawa Abu and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of general internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Challenges associated with managing treatment complications in an older patient with cardiac amyloidosis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weijia WangDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Weijiawang87@gmail.com.ORCID 0000-0002-9435-0145
Jane S SaczynskiDepartment of Pharmacy and Health System Sciences, Northeastern University, Boston, MA, USA.
Darleen LessardDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Robert J GoldbergDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
David ParishDepartment of Medicine, School of Medicine, Mercer University, Macon, GA, USA.
Robert HelmDepartment of Medicine, School of Medicine, Boston University, Boston, MA, USA.
Catarina I KiefeDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Katherine TrymbulakFrank H. Netter M.D. School of Medicine at Quinnipiac University, North Haven, CT, USA.
Jordy MehawejDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Hawa AbuDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Robert HaywardKaiser Permanente Santa Clara Medical Center, Santa Clara, CA, USA.
Joel GoreDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Jerry H GurwitzDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
David D McManusDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Funding

Detecting bleeding events using EHRs for prediction in AfibR01HL137794 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., YU, HONG · 2018 to 2021
$3.3M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
Smartwatch Monitoring for Atrial Fibrillation After StrokeR01HL137734 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CHON, KI H, MCMANUS, DAVID D. · 2018 to 2021
$3.1M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01HL126911NHLBI NIH HHS R01 HL137734NHLBI NIH HHS R01 HL137794NHLBI NIH HHS R01 HL141434
6 · The paper itself

Abstract

backgroundIn older patients with atrial fibrillation (AF), physical, cognitive, and psychosocial limitations are prevalent. The prognostic value of these conditions for major bleeding is unclear.

objectiveTo determine whether geriatric conditions are prospectively associated with major bleeding in older patients with AF on anticoagulation.

designMulticenter cohort study with 2-year follow-up from 2016 to 2020 in Massachusetts and Georgia from cardiology, electrophysiology, and primary care clinics.

participantsDiagnosed with AF, age 65 years or older, CHA MAIN MEASURES: A six-component geriatric assessment of frailty, cognitive function, social support, depressive symptoms, vision, and hearing. Main outcome was major bleeding adjudicated by a physician panel. KEY

resultsAt baseline, participants were, on average, 75.5 years old and 49% were women. Mean CHA

conclusionsIn older patients with AF taking anticoagulants, cognitive impairment and frailty were independently associated with major bleeding.

Indexed as

Atrial FibrillationFrailtyStrokeAgedAnticoagulantsCohort StudiesFemaleHemorrhageHumansMalePrognosisRisk AssessmentRisk FactorsAnticoagulants

Identifiers

PMID35102482
PMCPMC9640487

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.