ArticleBiogerontology2022
Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production.
Article in Biogerontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Skeletal Muscle Aging: Lessons From Teleosts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Review
- Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species.European journal of histochemistry : EJH · 2024Article
- Review
- Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri.Biogerontology · 2023Article
- Administration of krill oil extends lifespan of fish Nothobranchius guentheri via enhancement of antioxidant system and suppression of NF-κB pathway.Fish physiology and biochemistry · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress including DNA damage, increased lipid and protein oxidation, is an important feature of aging. Diosgenin (DG) has been shown to have diverse biological effects, including amelioration of aging-related cognition deficits, but the anti-aging activity of DG has not been tested before in animal models. In the present study, we clearly demonstrated that dietary intake of DG extended both mean and maximum lifespans of the male fish Nothobranchius guentheri by approximately 3.23 and 3.67 weeks, respectively, reduced the accumulation of lipofuscin (LF) in the gills and senescence-associated-β-galactosidase (SA-β-Gal) in the caudal fins, and lowered the levels of protein oxidation, lipid peroxidation and reactive oxygen species (ROS) in the muscles, indicating that DG possesses rejuvenation and anti-aging property. We also showed that DG enhanced the activity of antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase, promoted the proteolytic activity of the ubiquitin-proteasome pathway, and suppressed the phosphatidylinositol 3-kinase/protein kinase/molecular target of rapamycin (PI3K/AKT/mTOR) signaling pathway. Altogether, this study highlights for the first time the rejuvenation and anti-aging property of the naturally occurring steroidal sapogenin DG. It also suggests that DG exerts its rejuvenation and anti-aging activity through modulation of multiple signaling pathways that play prominent roles in ROS production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.