Evidence map›Paper›PMID 35102454›Full record

ReviewCellular and molecular neurobiology2023

Role of Ferroptosis in Stroke.

Yunfei Xu, Kexin Li, Yao Zhao, Lin Zhou, Ying Liu, Jie Zhao

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
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  10. Identification of 4,5,6,7-Tetrabromo-1bioRxiv : the preprint server for biology · 2026
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yunfei XuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.ORCID http://orcid.org/0000-0001-8017-9263
Kexin LiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.ORCID http://orcid.org/0000-0002-6649-0415
Yao ZhaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.ORCID http://orcid.org/0000-0001-9233-0805
Lin ZhouDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.ORCID http://orcid.org/0000-0002-1823-6228
Ying LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. liu1977ying@126.com.ORCID http://orcid.org/0000-0003-3392-5977
Jie ZhaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. steelzj@csu.edu.cn.ORCID http://orcid.org/0000-0003-3760-4038
Central South University · CN

Funding

Fundamental Research Funds for Central Universities of the Central South University 2020zzts222National Natural Science Foundation of China 30901555National Natural Science Foundation of China 30972870National Natural Science Foundation of China 81360080National Natural Science Foundation of China 81373147National Natural Science Foundation of China 81571880National Natural Science Foundation of China 82172147Natural Science Foundation of Hunan Province 2016JJ2157Natural Science Foundation of Hunan Province 2021JJ30900
6 · The paper itself

Abstract

Stroke is a common and serious nervous system disease caused by the rupture or blockage of the cardiovascular system. It causes millions of deaths and disabilities every year, which is a huge burden on humanity. It may be induced by thrombosis, hypertension, hyperlipidemia, hyperglycemia, smoking, advanced age and so on. According to different causes, stroke can be generally divided into hemorrhagic stroke and ischemic stroke, whose pathogenesis and treatment are quite different. Ferroptosis is a new type of cell death first defined in 2012, which is characterized by non-apoptotic, iron-dependent, and over-accumulated lipid peroxides. Excess lipid reactive oxygen species produced during ferroptosis eventually leads to oxidative cell death. Ferroptosis has been shown to occur and play an important role in tumors, neurological diseases, kidney injury, and ischemia-reperfusion injury. Ferroptosis is also closely related to the pathogenesis of stroke. Moreover, scientists have successfully intervened in the process of stroke in animal models by regulating ferroptosis, indicating that ferroptosis is a new potential target for the treatment of stroke. This paper systematically summarizes the involvement and role of ferroptosis in the pathogenesis of stroke and predicts the potential of ferroptosis in the treatment of stroke. Ferroptosis in stroke. Stroke induces iron overload and lipid metabolism disorders. Elevated iron catalyzes lipid peroxidation and eventually triggers ferroptosis. Conversely, the GSH/GPX4 pathway, as well as CoQ10, Fer-1, and Lip-1, inhibits lipid peroxidation and, thus, alleviates ferroptosis. GSH glutathione; GPX4 glutathione peroxidase 4; CoQ10 coenzyme Q10; Lip-1 liproxstatin-1; Fer-1 ferostatin-1.

Indexed as

FerroptosisNervous System DiseasesStrokeAnimalsCell DeathIronLipid PeroxidationIronFerroptosisHemorrhageIschemiaStroke

Identifiers

PMID35102454
PMCPMC11415219
OpenAlexW4210345586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.