Evidence map›Paper›PMID 35101965›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate.

Stephanie A Getz, Kamran Tariq, Dylan H Marchand, Conor R Dickson, James R Howe Vi, Patrick D Skelton, Wei Wang, Meijie Li, Jeremy M Barry, Jennifer Hong and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. PTEN Subcellular Localization Dictates Function.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Stephanie A GetzDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.ORCID 0000-0002-3995-2725
Kamran TariqDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.ORCID 0000-0003-0074-4475
Dylan H MarchandDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405.
Conor R DicksonDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405.
James R Howe ViDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.
Patrick D SkeltonDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.ORCID 0000-0002-6691-9904
Wei WangDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.
Meijie LiDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.
Jeremy M BarryDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405.
Jennifer HongDepartment of Surgery and Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755.
Bryan W LuikartDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755 bryan.w.luikart@dartmouth.edu.ORCID 0000-0002-3181-6075
Dartmouth College · USUniversity of Vermont · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
The Impact of PTEN Signaling on Neuronal Form and FunctionR01MH097949 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRYAN W LUIKART · 2012 to 2026
$7.4M
Mechanisms of Cognitive Impairment Following Early-Life SeizuresR01NS108765 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HOLMES, GREGORY L. · 2018 to 2022
$1.9M
NCI NIH HHS P30 CA023108NIMH NIH HHS R01 MH097949NINDS NIH HHS R01 NS108765
6 · The paper itself

Abstract

Phosphatase and tensin homolog (PTEN) is a major negative regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway. Loss-of-function mutations in

Indexed as

Autism Spectrum DisorderBrainMicrotubulesPTEN PhosphohydrolaseAnimalsFemaleHumansMaleMiceNeuronal PlasticityPolymerizationSirolimusTOR Serine-Threonine KinasesPTEN PhosphohydrolasePTEN protein, humanPten protein, mouseSirolimusTOR Serine-Threonine KinasesautismcytoskeletondendritemicrotubulenavigationPTEN

Identifiers

PMID35101965
PMCPMC8916761
OpenAlexW4210285569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.