ArticleProceedings of the National Academy of Sciences of the United States of America2022
The embryonic node behaves as an instructive stem cell niche for axial elongation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The notochord: development, disease and stem cell-based modelling.Development (Cambridge, England) · 2026Review
- Cell biology of the chick organizer: Origins, composition, population dynamics and fate.Cells & development · 2025Review
- The organizer as a cooperative of signaling cells for neural induction.bioRxiv : the preprint server for biology · 2025Article
- Timely TGFβ signalling inhibition induces notochord.Nature · 2025Article
- Distinct molecular profile of the chick organizer as a stem zone during axial elongation.Open biology · 2024Article
- Cell lineage-guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantitative Experimental Embryology: A Modern Classical Approach.Journal of developmental biology · 2022Review
- A niche for axial stem cells - A cellular perspective in amniotes.Developmental biology · 2022Article
- The unappreciated generative role of cell movements in pattern formation.Royal Society open science · 2022Review
- Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny.eLife · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
In warm-blooded vertebrate embryos (mammals and birds), the axial tissues of the body form from a growth zone at the tail end, Hensen's node, which generates neural, mesodermal, and endodermal structures along the midline. While most cells only pass through this region, the node has been suggested to contain a small population of resident stem cells. However, it is unknown whether the rest of the node constitutes an instructive niche that specifies this self-renewal behavior. Here, we use heterotopic transplantation of groups and single cells and show that cells not destined to enter the node can become resident and self-renew. Long-term resident cells are restricted to the posterior part of the node and single-cell RNA-sequencing reveals that the majority of these resident cells preferentially express G2/M phase cell-cycle-related genes. These results provide strong evidence that the node functions as a niche to maintain self-renewal of axial progenitors.
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