ArticleProceedings of the National Academy of Sciences of the United States of America2022
Novel stimuli evoke excess activity in the mouse primary visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
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- Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway.eLife · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Higher-level spatial prediction in natural vision across mouse visual cortex.PLoS computational biology · 2026Article
- View-invariant representations in ancestral cortex.Science advances · 2025Article
- Exploring the Architectural Biases of the Cortical Microcircuit.Neural computation · 2025Article
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- Oddball Evoked Deviant Responses Reflect Complex Context-Dependent Expectations in Mouse V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Learning Temporal Relationships Between Symbols with Laplace Neural Manifolds.Computational brain & behavior · 2025Article
- Predictive coding: A distinction - without a difference.Current biology : CB · 2024Article
- Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.Cell reports · 2024Article
- Article
- Mixing novel and familiar cues modifies representations of familiar visual images and affects behavior.Cell reports · 2024Article
- Exploring the Architectural Biases of the Canonical Cortical Microcircuit.bioRxiv : the preprint server for biology · 2024Article
- Revealing the mechanisms of semantic satiation with deep learning models.Communications biology · 2024Article
- Fast adaptation to rule switching using neuronal surprise.PLoS computational biology · 2024Article
- Synthetic surprise as the foundation of the psychedelic experience.Neuroscience and biobehavioral reviews · 2024Review
- Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A power law describes the magnitude of adaptation in neural populations of primary visual cortex.Nature communications · 2023Article
- Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To explore how neural circuits represent novel versus familiar inputs, we presented mice with repeated sets of images with novel images sparsely substituted. Using two-photon calcium imaging to record from layer 2/3 neurons in the mouse primary visual cortex, we found that novel images evoked excess activity in the majority of neurons. This novelty response rapidly emerged, arising with a time constant of 2.6 ± 0.9 s. When a new image set was repeatedly presented, a majority of neurons had similarly elevated activity for the first few presentations, which decayed to steady state with a time constant of 1.4 ± 0.4 s. When we increased the number of images in the set, the novelty response's amplitude decreased, defining a capacity to store ∼15 familiar images under our conditions. These results could be explained quantitatively using an adaptive subunit model in which presynaptic neurons have individual tuning and gain control. This result shows that local neural circuits can create different representations for novel versus familiar inputs using generic, widely available mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.