Evidence map›Paper›PMID 35101894›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

γδ T Cells Activated in Different Inflammatory Environments Are Functionally Distinct.

Deming Sun, Nymph Chan, Hui Shao, Willi K Born, Henry J Kaplan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  9. Review
  10. γδ T Cells in Skin Inflammation.Critical reviews in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Deming SunDoheny Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA; dsun@doheny.org.ORCID 0000-0003-4851-0416
Nymph ChanDoheny Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Hui ShaoDepartment of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY.ORCID 0000-0001-7566-6921
Willi K BornDepartment of Biomedical Research, National Jewish Health Center, Denver, CO; and.ORCID 0000-0002-0613-876X
Henry J KaplanSchool of Medicine, Saint Louis University, St. Louis, MO.ORCID 0000-0003-1799-5692
Doheny Eye Institute · USNational Jewish Health · USSaint Louis University · USUniversity of Louisville · US

Funding

Role of IL-17+ Autoreactive T Cells in Experimental Autoimmune Uveitis (EAU)R01EY018827 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 2009 to 2023
$4.8M
Regulation by Gammadelta T Cells of Autoimmune Uveitis (EAU)R01EY022403 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 2012 to 2015
$1.6M
NEI NIH HHS R01 EY018827NEI NIH HHS R01 EY022403
6 · The paper itself

Abstract

γδ T cells are important immunoregulatory cells in experimental autoimmune uveitis (EAU), and the activation status of γδ T cells determines their disease-enhancing or inhibitory effects. Because γδ T cells can be activated via various pathways, we questioned whether the nature of their activation might impact their function. In this study, we show that γδ T cells activated under different inflammatory conditions differ greatly in their functions. Whereas anti-CD3 treatment activated both IFN-γ

Indexed as

5'-NucleotidaseAnimalsAutoimmune DiseasesCytokinesDendritic CellsFemaleInterferon-gammaInterleukin-17Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaTh17 CellsTh1 CellsT-Lymphocyte Subsets5'-NucleotidaseCytokinesIFNG protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-17Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID35101894
PMCPMC9012081
OpenAlexW4210465811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.