Evidence map›Paper›PMID 35101647›Full record

ArticleEuropean journal of medicinal chemistry2022

Neuropeptide B/W receptor 1 peptidomimetic agonists: Structure-activity relationships and plasma stability.

Thuy Nguyen, Ann M Decker, Rodney W Snyder, Emma C Tonetti, Thomas F Gamage, Yanan Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thuy NguyenCenter for Drug Discovery, RTI International, Research Triangle Park, NC, 27709, USA. Electronic address: tnguyen@rti.org.
Ann M DeckerCenter for Drug Discovery, RTI International, Research Triangle Park, NC, 27709, USA.
Rodney W SnyderCenter for Drug Discovery, RTI International, Research Triangle Park, NC, 27709, USA.
Emma C TonettiCenter for Drug Discovery, RTI International, Research Triangle Park, NC, 27709, USA.
Thomas F GamageCenter for Drug Discovery, RTI International, Research Triangle Park, NC, 27709, USA.
Yanan ZhangCenter for Drug Discovery, RTI International, Research Triangle Park, NC, 27709, USA.
RTI International · US

Funding

Development of Novel Neuropeptide B/W Receptor 1 AgonistsR03TR003370 · NCATS · RESEARCH TRIANGLE INSTITUTE · PI NGUYEN, THUY · 2020 to 2020
$215k
NCATS NIH HHS R03 TR003370
6 · The paper itself

Abstract

Neuropeptides B and W (NPB and NPW) are endogenous ligands of the Neuropeptide B/W Receptor 1 (NPBWR1) which has been implicated in a wide range of functions including regulation of pain and energy homeostasis. There is currently little information on the structure-activity relationships (SAR) of these two neuropeptides. In a quest to develop stable and potent NPBWR1 peptidomimetic agonists, we performed systematic SAR by truncation, Alanine/Glycine and d-amino acid scans, and replacement with unnatural amino acids. Evaluation in the NPBWR1 calcium assay revealed that the C-terminal GRAAGLL and N-terminal WYK regions constitute the two-epitope pharmacophore for NPBWR1 agonism. Replacement of the N-terminal Trp with its desaminoTrp residue resulted in compound 30 which exhibited nanomolar potency comparable to the endogenous NPB at NPBWR1 (Calcium assay: EC

Indexed as

NeuropeptidesPeptidomimeticsAnimalsRatsReceptors, NeuropeptideStructure-Activity Relationshipneuropeptide BNeuropeptidesPeptidomimeticsReceptors, NeuropeptideG protein coupled receptorNeuropeptide BNeuropeptide B/W receptor 1Neuropeptide WPlasma stabilityStructure-activity relationship

Identifiers

PMID35101647
PMCPMC8891040
OpenAlexW4207019104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.