ArticleInternational journal of cardiology2022
Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas.
Article in International journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Relative Contributions of Functional Capacity and Inflammatory Activity to Quality of Life in Heart Failure with Preserved Ejection Fraction.Biomedicines · 2026Article
- Changes in Diastolic Parameters and Their Association With Changes in Health Status: Insights From TOPCAT.Journal of Cardiac Failure. Intersections · 2025Article
- A retrospective study on the clinical significance of cardiac computed tomography in heart failure patients with preserved ejection fraction.Annals of translational medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPatients with heart failure with preserved ejection fraction (HFpEF) have poor health-related quality of life (HR-QoL). However, the relationship between HR-QoL measures and the alterations of cardiac structure and function that are present in patients with HFpEF remains unknown.
aimsTo study the associations between HR-QoL and echocardiographic parameters in HFpEF.
methodsRegression modelling in patients from TOPCAT-Americas who had both HR-QoL questionnaires and a baseline echocardiogram.
resultsA total of 631 patients (36% of the TOPCAT-Americas population) had both echocardiographic and HR-QoL at baseline. KCCQ-23 Overall Summary Score (OSS; 0-100 points) was negatively (higher echocardiographic values-poorer/lower HR-QoL scores) associated with left ventricular end-diastolic diameter (LVEDD: β = -3.56 [-7.00 to -0.13] points-per-1 cm, P = 0.042), interventricular septum thickness (β = -1.31 [-2.19 to -0.42] points-per-1 mm, P = 0.004), posterior wall thickness (β = -1.57 [-2.52 to -0.63] points-per-1 mm, P = 0.001 and left atrial width (β = -3.27 [-6.39 to -0.15], P = 0.040) points-per-1 cm, and positively (higher echocardiographic values-better/higher HR-QoL scores) associated with left ventricular end-diastolic volume index (LVEDVi: β = 0.23 [0.09 to 0.37] points-per-1 ml/m2, P = 0.002) and left ventricular end-systolic volume index (LVESVi: β = 0.41 [0.18 to 0.63] points-per-1 ml/m2, P < 0.001). Body mass index (BMI: β = -0.74 [-1.02 to -0.47] points-per-1Kg/m2, P < 0.001), diabetes (β = -6.01 [-10.05 to -1.97], P = 0.004), and asthma (β = -6.78 [-13.52 to -0.04], P = 0.049) were negatively associated with OSS. A similar pattern of associations was observed for KCCQ-23 Clinical Summary Score, EQ5D-VAS and NYHA class.
conclusionIn patients with HFpEF, HR-QoL measures were associated with cardiac structure and function alterations. Extra-cardiac factors were also associated with HR-QoL, which may influence HR-QoL results when testing cardiovascular drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.