Evidence map›Paper›PMID 35101425›Full record

ArticleJournal of lipid research2022

Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis.

Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E Turk, Tomasz Wietecha, Yongjun Liu, Karin E Bornfeldt, Kevin D O'Brien, Alan Chait, Laura J den Hartigh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Tanshinone IIA alleviates atherosclerosis in LDLRFrontiers in pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Diego GomesDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.
Shari WangDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.
Leela GoodspeedDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.
Katherine E TurkDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.
Tomasz WietechaDiabetes Institute, University of Washington, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Yongjun LiuDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
Karin E BornfeldtDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Kevin D O'BrienDiabetes Institute, University of Washington, Seattle, WA, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Alan ChaitDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.
Laura J den HartighDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA. Electronic address: lauradh@u.washington.edu.
University of Washington · USUniversity of Wisconsin–Madison · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHAIT, ALAN · 2008 to 2019
$23.5M
Triglycerides, Diabetes and Cardiovascular DiseaseP01HL151328 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 2020 to 2026
$19.6M
Identifying new strategies for prevention of cardiovascular complications of diabetesR35HL150754 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E · 2020 to 2025
$6.2M
Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA SupplementationK01AT007177 · NCCIH · UNIVERSITY OF WASHINGTON · PI DEN HARTIGH, LAURA JANE · 2013 to 2017
$649k
NCCIH NIH HHS K01 AT007177NHLBI NIH HHS P01 HL092969NHLBI NIH HHS P01 HL151328NHLBI NIH HHS R35 HL150754NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and contrast atherosclerosis in mice given Ldlr-ASO with those bearing genetic Ldlr deficiency. To promote atherosclerosis, male and female C57Bl6/J mice were either given weekly injections of Ldlr-ASO (5 mg/kg once per week) or genetically deficient in Ldlr (Ldlr

Indexed as

AtherosclerosisHypercholesterolemiaAnimalsCholesterolDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPharmaceutical PreparationsReceptors, LDLCholesterolPharmaceutical PreparationsReceptors, LDLanimal modelsantisense oligonucleotidesfast-phase liquid chromatographyhepatic inflammationhyperlipidemiainflammationliverreceptors/lipoproteinserum amyloid A

Identifiers

PMID35101425
PMCPMC8953673
OpenAlexW4210509744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.