ArticleeLife2022
Charting brain growth and aging at high spatial precision.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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127citing papers in PubMed
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Who cites it
127 citing papers in PubMed.
- Accelerated Brain Aging Identifies Functional Vulnerability Beyond Chronological Age in Multiple Sclerosis.Sensors (Basel, Switzerland) · 2026Trial
- Normative Modeling of Amygdala Subfields and Disease-Specific Vulnerabilities Across Neurological Disorders.Neuroscience bulletin · 2026Article
- Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Charting confidence in white matter brain charts: enabling study planning through stability validation.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- Latent representations of early brain development: A multivariate normative model of brain structure and behaviour.Developmental cognitive neuroscience · 2026Article
- A Researcher's guide to rodent models of Down syndrome: Recent insights and translational perspectives.STAR protocols · 2026Review
- NeuroLangSeg: Language-Guided Subcortical Segmentation with Pseudo-Supervision and Anatomical-Linguistic Validation.Proceedings of machine learning research · 2026Article
- miniMORPH: A Morphometry Pipeline for Low-Field MRI in Infants.Human brain mapping · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Lifespan normative modeling of brain microstructure.Nature communications · 2026Article
- Developing a multi-modal neuroimaging-based BrainAge model across childhood.bioRxiv : the preprint server for biology · 2026Article
- Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Cerebellar growth is associated with domain-specific cerebral maturation and socio-linguistic behavior.Nature communications · 2026Article
- Brain charts for neuroanatomical sex differences across the human lifespan.bioRxiv : the preprint server for biology · 2026Article
- Normative modeling reveals functional connectivity heterogeneity in internet gaming disorder.Annals of general psychiatry · 2026Article
- Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.medRxiv : the preprint server for health sciences · 2026Article
- Structural brain imaging biomarkers for predicting seizure recurrence after a first unprovoked seizure.Epilepsia open · 2026Article
- Mapping cerebellar subregional volumes and heterogeneity in schizophrenia spectrum disorders and violence.European archives of psychiatry and clinical neuroscience · 2026Article
- Normative modeling of MEG brain oscillations across the human lifespan.Communications biology · 2026Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Saige RutherfordDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.ORCID 0000-0003-3006-9044
Charlotte FrazaDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.
Richard DingaDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.
Seyed Mostafa KiaDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.ORCID 0000-0002-7128-814X
Thomas WolfersDepartment of Psychology, University of Oslo, Oslo, Norway.
Mariam ZabihiDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.
Pierre BerthetDepartment of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0002-6878-6842
Amanda WorkerDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Serena VerdiCentre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Derek AndrewsThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California, Davis, Sacramento, United States.
Laura Km HanAmsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.
Johanna Mm BayerCentre for Youth Mental Health, University of Melbourne, Melbourne, Australia.ORCID 0000-0003-4891-6256
Paola DazzanDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Phillip McGuireDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom.
Roel T MockingDepartment of Psychiatry, Amsterdam UMC, Location AMC, Amsterdam, Netherlands.
Aart ScheneDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.
Chandra SripadaDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.ORCID 0000-0001-9025-6453
Ivy F TsoDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
Elizabeth R DuvalDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
Soo-Eun ChangDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
Brenda Wjh PenninxAmsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.
Mary M HeitzegDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
S Alexandra BurtDepartment of Psychology, Michigan State University, East Lansing, United States.
Luke W HydeDepartment of Psychology, University of Michigan, Ann Arbor, United States.
David AmaralThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California, Davis, Sacramento, United States.
Christine Wu NordahlThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California, Davis, Sacramento, United States.
Ole A AndreasssenNorwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.
Roland ZahnCentre for Affective Disorders at the Institute of Psychiatry, King's College London, London, United Kingdom.
Henricus G RuheDonders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.
Christian Beckmann *Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.
Andre F Marquand *Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, Netherlands.ORCID 0000-0001-5903-203X
Funding
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9MABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MAdolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5MEuropean Research Council 101001118Medical Research Council G0902304Medical Research Council MR/S003444/1Medical Research Council MR/T017538/1MRF_ C0439NCATS NIH HHS UL1 TR002240NICHD NIH HHS P50 HD093079NICHD NIH HHS R01 HD093334NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIDCD NIH HHS R01 DC011277NIMH NIH HHS K23 MH108823NIMH NIH HHS R01 MH103371NIMH NIH HHS R01 MH104438NIMH NIH HHS R01 MH107741NIMH NIH HHS R01 MH122491NIMH NIH HHS UG3 MH114249Wellcome Trust 098369/Z/12/ZWellcome Trust 215698Wellcome Trust 215698/Z/19/ZZonMw 91716415
Abstract
Defining reference models for population variation, and the ability to study individual deviations is essential for understanding inter-individual variability and its relation to the onset and progression of medical conditions. In this work, we assembled a reference cohort of neuroimaging data from 82 sites (N=58,836; ages 2-100) and used normative modeling to characterize lifespan trajectories of cortical thickness and subcortical volume. Models are validated against a manually quality checked subset (N=24,354) and we provide an interface for transferring to new data sources. We showcase the clinical value by applying the models to a transdiagnostic psychiatric sample (N=1985), showing they can be used to quantify variability underlying multiple disorders whilst also refining case-control inferences. These models will be augmented with additional samples and imaging modalities as they become available. This provides a common reference platform to bind results from different studies and ultimately paves the way for personalized clinical decision-making.
Indexed as
Big DataModels, StatisticalAdolescentAdultAgedAged, 80 and overAgingBrainChildChild, PreschoolCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedbig databrain chartgrowth charthumanindividual predictionlifespanneurosciencenormative model
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.