ArticleEye and vision (London, England)2022
Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression.
Article in Eye and vision (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association of physical activity, sedentary behaviour, sleep and myopia in children and adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2025Pooled it
- Effect of Lutein Ester Supplement on Choroidal Thickness in Children: A Randomized Controlled Trial.Translational vision science & technology · 2025Trial
- Choroidal Changes During and After Discontinuing Long-Term 0.01% Atropine Treatment for Myopia Control.Investigative ophthalmology & visual science · 2024Trial
- Longitudinal Changes in Choroidal Thickness Across the Eye in Young Children With Premyopia.Investigative ophthalmology & visual science · 2026Article
- Subfoveal Choroidal Thickness is Independently Associated with Axial Length and Myopia in Preschool Children: A Swept-Source Optical Coherence Tomography Study.Ophthalmology and therapy · 2026Article
- Choroidal Structural and Vascular Changes During Myopia Progression and in Response to Myopia Control Interventions: A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Repeated low-intensity red light combined with defocus-incorporated multiple segments (DIMS) spectacles for controlling myopia progression in children.American journal of translational research · 2026Article
- Quantitative analysis of choroidal and retinal thickness and blood flow in a rat model of lens-induced myopia using OCTA.PloS one · 2026Article
- Repeatability, reproducibility, and agreement for three optical coherence tomography instruments.BMC ophthalmology · 2025Article
- Intensive outdoor activity for 1 week increases choroidal thickness in Japanese schoolchildren: a prospective observational study.BMC ophthalmology · 2025Observational
- Thinning Choroidal Thickness and Flattening Morphology of Higher Myopia Eyes in Chinese Adults with Anisometropic Myopia: A Comparative Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Early retinal and choroidal changes in the macula region associated with axial length in myopic children and adolescents based on swept-source OCTA.Frontiers in medicine · 2025Article
- Differences in macular structure and microvasculature between high myopia and non-high myopia.Frontiers in medicine · 2025Article
- Structural changes in the retina and choroid in patients with different degrees of myopia.Scientific reports · 2024Article
- The Macular Choroidal Thickness in Danish Children with Myopia After Two-Year Low-Dose Atropine and One-Year Wash-Out: A Placebo-Controlled, Randomized Clinical Trial.Ophthalmology and therapy · 2024Article
- Choroidal Vascularity and Axial Length Elongation in Highly Myopic Children: A 2-Year Longitudinal Investigation.Investigative ophthalmology & visual science · 2024Observational
- Longitudinal Changes in Choroidal Thickness Varied With Refractive Progression in Myopic and Non-Myopic Children: A Two-Year Cohort Study.Investigative ophthalmology & visual science · 2024Article
- Analysis of research hotspots and trends in pediatric ophthalmopathy based on 10 years of WoSCC literature.Frontiers in pediatrics · 2024Article
- Article
- Choroidal thickness, myopia, and myopia control interventions in children: a Meta-analysis and systemic review.International journal of ophthalmology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWith increasing axial length and myopia progression, the micro-structure of the retina and choroid gradually changes. Our study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes in choroidal thickness and myopia progression.
methodsAn exploratory analysis of a randomized trial was performed. Children (n = 168, aged 7 to 12 years) with myopia from - 0.75 dioptre (D) to - 4.00 D were enrolled in this prospective longitudinal study. Cycloplegic refraction, axial length (AL), retinal and choroidal thicknesses were measured at baseline and at 1- and 2-year follow-ups. "Rapid progression myopia" was defined as increasing in myopia > 1.00 D and "stable progression myopia" was ≤ 1.00 D during the 2-year follow-up. Factors affecting the changes in choroidal thickness were analysed using linear mixed models.
resultsAL significantly increased by 0.67 ± 0.24 mm with a myopic shift of - 1.50 ± 0.64 D over the 2 years. The overall retinal thickness increased from 251.12 ± 15.91 µm at baseline to 253.47 ± 15.74 µm at the 2-year follow-up (F = 23.785, P < 0.001). The subfoveal choroidal thickness decreased from 231.03 ± 54.04 µm at baseline to 206.53 ± 59.71 µm at the 2-year follow-up (F = 73.358, P < 0.001). Choroidal thinning was significantly associated with AL elongation (β = - 43.579 μm/mm, P = 0.002) and sex (β = - 17.258, P = 0.001). Choroidal thickness continued to decrease in subjects with rapid progression (F = 92.06, P < 0.001) but not in those with steady progression (F = 2.23, P = 0.119).
conclusionSignificant choroidal thinning was observed and was associated with rapid progression and sex. These findings indicate a need to understand the role of the choroid in eye growth and myopia development. SYNOPSIS/PRECIS: The macular choroidal thickness of myopic children is relevant to different degrees of myopic progression in this 2-year longitudinal study. These findings suggest that control of choroidal thickness might work to regulate human ocular growth. Trial registration Chinese Clinical Trial Register (ChiCTR): ChiCTR-INR-16007722.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.