Evidence map›Paper›PMID 35101114›Full record

ArticleGenome biology2022

AGAMEMNON: an Accurate metaGenomics And MEtatranscriptoMics quaNtificatiON analysis suite.

Giorgos Skoufos, Fatemeh Almodaresi, Mohsen Zakeri, Joseph N Paulson, Rob Patro, Artemis G Hatzigeorgiou, Ioannis S Vlachos

Abstract read
In one paragraph

Article in Genome biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Where the Patterns Are: Repetition-Aware Compression for Colored de Bruijn GraphsJournal of computational biology : a journal of computational molecular cell biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giorgos Skoufos *Department of Electrical & Computer Engineering, University of Thessaly, 38221, Volos, Greece. gskoufos@uth.gr.
Fatemeh Almodaresi *Department of Computer Science, University of Maryland, College Park, MD, USA.
Mohsen ZakeriDepartment of Computer Science, University of Maryland, College Park, MD, USA.
Joseph N PaulsonDepartment of Data Sciences, Genentech Inc., South San Francisco, CA, USA.
Rob PatroDepartment of Computer Science, University of Maryland, College Park, MD, USA.
Artemis G Hatzigeorgiou *Department of Electrical & Computer Engineering, University of Thessaly, 38221, Volos, Greece. arhatzig@uth.gr.
Ioannis S Vlachos *Cancer Research Institute | HMS Initiative for RNA Medicine | Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. ivlachos@bidmc.harvard.edu.ORCID 0000-0002-8849-808X

Funding

A Modular Framework for Accurate, Interpretable, and Reproducible Analysis of Long Read RNA-Seq DataR01HG009937 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Isaiah Love, Robert Patro · 2018 to 2026
$2.8M
NHGRI NIH HHS R01 HG009937
6 · The paper itself

Abstract

We introduce AGAMEMNON ( https://github.com/ivlachos/agamemnon ) for the acquisition of microbial abundances from shotgun metagenomics and metatranscriptomic samples, single-microbe sequencing experiments, or sequenced host samples. AGAMEMNON delivers accurate abundances at genus, species, and strain resolution. It incorporates a time and space-efficient indexing scheme for fast pattern matching, enabling indexing and analysis of vast datasets with widely available computational resources. Host-specific modules provide exceptional accuracy for microbial abundance quantification from tissue RNA/DNA sequencing, enabling the expansion of experiments lacking metagenomic/metatranscriptomic analyses. AGAMEMNON provides an R-Shiny application, permitting performance of investigations and visualizations from a graphics interface.

Indexed as

MetagenomeMetagenomicsSequence Analysis, DNASequence Analysis, RNAComputational metagenomicsIdentification of contaminantsMicrobiomeQuantification of microbial abundancesTime- and space-efficient indexing/alignment

Identifiers

PMID35101114
PMCPMC8802518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.