ArticleChild and adolescent psychiatry and mental health2022
Developmental brain structural atypicalities in autism: a voxel-based morphometry analysis.
Article in Child and adolescent psychiatry and mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07182331 (Effects of cTBS on Sensory Integration in Children With Autism Spectrum Disorder), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of cTBS on Sensory Integration in Children With Autism Spectrum Disorder: A Randomized, Sham-Controlled Study Integrating Genetic Markers, MRI, fNIRS, and Temporal Binding Tasks
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Brain Cortical Volume and Thickness Abnormalities in Autism Spectrum Disorder Aged 2-4 Years: a Structural MRI Comparative Study.Journal of autism and developmental disorders · 2026Article
- Gray matter subtyping with SuStaIn reveals neuroanatomical patterns in autism spectrum disorder.Brain imaging and behavior · 2026Article
- Changes in Functional Brain Activity in School-Age Children 10 Years Later: A Resting State Functional Magnetic Resonance Imaging Study.Psychiatry investigation · 2026Article
- Bridging Brain Science and Technology: How AI Is Shaping the Future of Neuroimaging in Autism.Diagnostics (Basel, Switzerland) · 2026Article
- Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Unraveling the Autism Spectrum Heterogeneity: Insights From ABIDE I Database Using Data/Model-Driven Permutation Testing Approaches.Brain and behavior · 2026Article
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- Identifying Two Autism Biotypes Using Multi-Task Learning Derived Individual-Specific Functional Connectivity.Journal of autism and developmental disorders · 2026Article
- Structural brain alterations associated with brain age may link to social dysfunction in male adults with autism spectrum disorder.Frontiers in neuroscience · 2026Article
- Salience Network in Autism: preliminary results on functional connectivity analysis in resting state.European archives of psychiatry and clinical neuroscience · 2025Article
- The Development of Lateralized Brain Oscillations in Infants: Lessons From Autism.Developmental psychobiology · 2025Article
- Diffusion trajectory of atypical morphological development in autism spectrum disorder.Communications biology · 2025Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Gray matter asymmetry alterations in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2024Article
- Exploring the most discriminative brain structural abnormalities in ASD with multi-stage progressive feature refinement approach.Frontiers in psychiatry · 2024Article
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder.Biomolecules · 2023Review
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Abnormal Brain Structure Is Associated with Social and Communication Deficits in Children with Autism Spectrum Disorder: A Voxel-Based Morphometry Analysis.Brain sciences · 2023Article
- Absence of associations with prefrontal cortex and cerebellum may link to early language and social deficits in preschool children with ASD.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStructural magnetic resonance imaging (sMRI) studies have shown atypicalities in structural brain changes in individuals with autism spectrum disorder (ASD), while a noticeable discrepancy in their results indicates the necessity of conducting further researches.
methodsThe current study investigated the atypical structural brain features of autistic individuals who aged 6-30 years old. A total of 52 autistic individuals and 50 age-, gender-, and intelligence quotient (IQ)-matched typically developing (TD) individuals were included in this study, and were assigned into three based cohorts: childhood (6-12 years old), adolescence (13-18 years old), and adulthood (19-30 years old). Analyses of whole-brain volume and voxel-based morphometry (VBM) on the sMRI data were conducted.
resultsNo significant difference was found in the volumes of whole-brain, gray matter, and white matter between the autism and TD groups in the three age-based cohorts. For VBM analyses, the volumes of gray matter in the right superior temporal gyrus and right inferior parietal lobule in the autism group (6-12 years old) were smaller than those in the TD group; the gray matter volume in the left inferior parietal lobule in the autism group (13-18 years old) was larger than that in the TD group; the gray matter volume in the right middle occipital gyrus in the autism group (19-30 years old) was larger than that in the TD group, and the gray matter volume in the left posterior cingulate gyrus in the autism group was smaller than that in the TD group.
conclusionAutistic individuals showed different atypical regional gray matter volumetric changes in childhood, adolescence, and adulthood compared to their TD peers, indicating that it is essential to consider developmental stages of the brain when exploring brain structural atypicalities in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.