Evidence map›Paper›PMID 35100878›Full record

ArticlemBio2021

The Staphylococcus aureus CidA and LrgA Proteins Are Functional Holins Involved in the Transport of By-Products of Carbohydrate Metabolism.

Jennifer L Endres, Sujata S Chaudhari, Xinyan Zhang, Janani Prahlad, Shu-Qi Wang, Lily A Foley, Sorin Luca, Jeffrey L Bose, Vinai C Thomas, Kenneth W Bayles

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Global Transcriptional Differences inAntibiotics (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Journal of bacteriology · 2025
    Article
  8. Review
  9. Interaction BetweenMicroorganisms · 2025
    Article
  10. Article
  11. Article
  12. Mutations in thebioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Loratadine Combats Methicillin-ResistantACS infectious diseases · 2024
    Article
  17. Article
  18. Beyond the double helix: the multifaceted landscape of extracellular DNA inFrontiers in cellular and infection microbiology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jennifer L EndresCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Sujata S ChaudhariCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Xinyan ZhangCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Janani PrahladCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Shu-Qi WangCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Lily A FoleyCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Sorin LucaCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
Jeffrey L BoseDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0003-3394-9557
Vinai C ThomasCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.ORCID 0000-0002-7886-0727
Kenneth W BaylesCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.
University of Nebraska Medical Center · USUniversity of Kansas Medical Center · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
The role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9M
The molecular control of bacterial programmed cell deathR01AI125589 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2016 to 2020
$1.9M
NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588NIAID NIH HHS R01 AI125589
6 · The paper itself

Abstract

The Staphylococcus aureus

Indexed as

BacteriophagesStaphylococcus aureusBacterial ProteinsCarbohydrate MetabolismMembrane ProteinsN-Acetylmuramoyl-L-alanine AmidasePyruvatesBacterial ProteinsMembrane ProteinsN-Acetylmuramoyl-L-alanine AmidasePyruvatesholinmembrane proteinpyruvateStaphylococcus aureustransporter

Identifiers

PMID35100878
PMCPMC8805020
OpenAlexW4210789274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.