Evidence map›Paper›PMID 35100823›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury.

Naomi S Shin, Arnaud Marlier, Leyuan Xu, TuKiet Lam, Lloyd G Cantley, Jian-Kan Guo

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Naomi S ShinSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut.
Arnaud MarlierSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut.
Leyuan XuSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-3071-9206
TuKiet LamDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.
Lloyd G CantleySection of Nephrology, Yale University School of Medicine, New Haven, Connecticut.
Jian-Kan GuoSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-8379-7091
Yale University · USW. M. Keck Foundation · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8M
PATHOPHYSIOLOGY OF ACUTE AND CHRONIC RENAL DISEASET32DK007276 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S., CANTLEY, LLOYD G · 1986 to 2022
$9.3M
Macrophage Function in Kidney RepairR01DK093771 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY · 2012 to 2026
$3.9M
Targeting macrophage persistence to prevent the AKI-to-CKD transitionK01DK120783 · NIDDK · YALE UNIVERSITY · PI XU, LEYUAN · 2019 to 2023
$698k
Generation of Macrophage Activation State-Specific Genetic Tools by A Synthetic Biology ApproachR21AI142316 · NIAID · YALE UNIVERSITY · PI CANTLEY, LLOYD G, GUO, JIANKAN · 2019 to 2020
$461k
NIAID NIH HHS R21 AI142316NIDDK NIH HHS K01 DK120783NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK079310NIDDK NIH HHS R01 DK093771NIDDK NIH HHS T32 DK007276
6 · The paper itself

Abstract

Renal tubular casts originating from detached epithelial cells after ischemia-reperfusion injury (IRI) can obstruct tubules and negatively impact glomerular filtration rate. Using multiphoton imaging of 400-μm-thick kidney sections, the distribution of casts and morphometric measurement of tubules was performed along the entire nephron for the first time. Tubular nuclei are shed before cell detachment, and visually occlusive casts (

Indexed as

NephronsReperfusion InjuryGlomerular Filtration RateHumansKidneyKidney Tubulesacute kidney failureischemia-reperfusion

Identifiers

PMID35100823
PMCPMC8897010
OpenAlexW4210246631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.