Evidence map›Paper›PMID 35100799›Full record

Observational studyAnaesthesiology intensive therapy2021

The diagnostic and prognostic value of mature and total adrenomedullin for sepsis: a prospective observational study.

Tetsu Yonaha, Toyoaki Maruta, Go Otao, Koji Igarashi, Sayaka Nagata, Takeshi Yano, Masahiko Taniguchi, Kazuo Kitamura, Isao Tsuneyoshi

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Anaesthesiology intensive therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tetsu YonahaDepartments of Anesthesiology and Intensive Care Unit, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Toyoaki MarutaDepartments of Anesthesiology and Intensive Care Unit, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Go OtaoDepartments of Anesthesiology and Intensive Care Unit, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Koji IgarashiResearch and Development Management, Bioscience Division, TOSOH Corporation, Kanagawa, Japan.
Sayaka NagataCirculatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Takeshi YanoDepartments of Anesthesiology and Intensive Care Unit, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Masahiko TaniguchiDepartments of Anesthesiology and Intensive Care Unit, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kazuo KitamuraCirculatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Isao TsuneyoshiDepartments of Anesthesiology and Intensive Care Unit, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
University of Miyazaki · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInformation about biologically active adrenomedullin (mature AM), a potential new biomarker for sepsis and septic shock, is limited. Here, we investigated the value of mature AM for diagnosis and outcome prediction in sepsis. MATERIAL AND

methodsPatients admitted to the intensive care unit (ICU) were retrospectively cate-gorised into non-sepsis or sepsis groups, according to the Sepsis-3 definitions. Plasma levels of mature and total (the sum of the levels of intermediate and mature forms) AM were measured, and their usefulness was compared with that of other sepsis biomarkers, such as procalcitonin and presepsin.

resultsOf the 98 patients analysed, 42 were assigned to the non-sepsis and 56 to the sepsis group. Mature and total AM levels on admission were significantly higher in patients with than in those without sepsis. The areas under the receiver operating characteristic curves (AUCs) of mature and total AM for diagnosing sepsis were 0.85 and 0.88, whereas those of procalcitonin and presepsin were 0.83 and 0.68, respectively. AUCs of mature and total AM for predicting 28-day mortality in patients with sepsis became significant on day 3 after admission. A good correlation between the AM forms was found, indicating that changes in their plasma levels may directly reflect each other.

conclusionsBecause mature and total AM levels increased significantly in patients with sepsis on admission, both forms may be used as reliable and early biomarkers for diagnosing sepsis according to the Sepsis-3 definitions. However, prediction of 28-day mortality in such patients would require several days of ICU stay.

Indexed as

SepsisShock, SepticAdrenomedullinBiomarkersHumansIntensive Care UnitsLipopolysaccharide ReceptorsPeptide FragmentsPrognosisRetrospective StudiesROC CurveAdrenomedullinBiomarkersLipopolysaccharide ReceptorsPeptide Fragmentspresepsin protein, humanadrenomedullinbiomarkersdiagnosismortality.sepsis

Identifiers

PMID35100799
PMCPMC10172949
OpenAlexW4245218172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.