ReviewJCO precision oncology2019
Basket Designs: Statistical Considerations for Oncology Trials.
Review in JCO precision oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Basket and umbrella trials in pediatric precision medicine: a systematic review of designs, opportunities, and challenges.BMC medical research methodology · 2026Pooled it
- Practical basket design for binary outcomes with control of family-wise error rate.BMC medical research methodology · 2023Trial
- Bayesian local exchangeability design for phase II basket trials.Statistics in medicine · 2022Trial
- A group-sequential randomized trial design utilizing supplemental trial data.Statistics in medicine · 2022Trial
- The role of the molecular tumor board: learnings from the ROME trial.NPJ precision oncology · 2026Article
- Bayesian model averaging for randomized dose optimization trials in multiple indications.Journal of biopharmaceutical statistics · 2026Article
- Biomarker-Driven Treatments for Ovarian Cancer: Moving Beyond HRD?International journal of women's health · 2026Review
- Multicenter basket trial for central nervous system tumors identifies activity of the CDK4/6 inhibitor abemaciclib in recurrent meningioma.Neuro-oncology · 2025Article
- Incorporating data from multiple ongoing trials for Bayesian two-stage phase II single-arm studies.Clinical trials (London, England) · 2025Article
- Reinforced Borrowing Framework: Leveraging Auxiliary Data for Individualized Inference.Statistics in medicine · 2024Article
- New clinical trial design borrowing information across patient subgroups based on fusion-penalized regression models.Statistical methods in medical research · 2024Article
- Review
- Basket Trials: Past, Present, and Future.Annual review of cancer biology · 2024Article
- Review
- Recent innovations in adaptive trial designs: A review of design opportunities in translational research.Journal of clinical and translational science · 2023Review
- Bayesian modelling strategies for borrowing of information in randomised basket trials.Journal of the Royal Statistical Society. Series C, Applied statistics · 2022Article
- Basket Trials: Review of Current Practice and Innovations for Future Trials.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Review
- Comparative Study of Bayesian Information Borrowing Methods in Oncology Clinical Trials.JCO precision oncology · 2022Review
- Article
- Statistical design considerations for trials that study multiple indications.Statistical methods in medical research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
Progress in the areas of genomics, disease pathways, and drug discovery has advanced into clinical and translational cancer research. The latest innovations in clinical trials have followed with master protocols, which are defined by inclusive eligibility criteria and devised to interrogate multiple therapies for a given tumor histology and/or multiple histologies for a given therapy under one protocol. The use of master protocols for oncology has become more common with the desire to improve the efficiency of clinical research and accelerate overall drug development. Basket trials have been devised to ascertain the extent to which a treatment strategy offers benefit to various patient subpopulations defined by a common molecular target. Conventionally conducted within the phase II setting, basket designs have become popular as drug developers seek to effectively evaluate and identify preliminary efficacy signals among clinical indications identified as promising in preclinical study. This article reviews basket trial designs in oncology settings and discusses several issues that arise with their design and analysis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.