Evidence map›Paper›PMID 35100442›Full record

ArticleFEBS letters2022

Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer's disease.

William J Behof, Clayton A Whitmore, Justin R Haynes, Adam J Rosenberg, Mohammed N Tantawy, Todd E Peterson, Fiona E Harrison, Robert B Beelman, Printha Wijesinghe, Joanne A Matsubara and 1 more

Abstract read
In one paragraph

Article in FEBS letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

William J BehofVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Clayton A WhitmoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Justin R HaynesVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Adam J RosenbergVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Mohammed N TantawyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Todd E PetersonVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Fiona E HarrisonDepartment of Medicine, Diabetes, Endocrinology & Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.
Robert B BeelmanDepartment of Food Science, Center for Plant and Mushroom Foods for Health, Penn State University, University Park, PA, USA.ORCID 0000-0002-6795-2984
Printha WijesingheDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Joanne A MatsubaraDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Wellington PhamVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-8408-7611

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Validation of Retinal Abeta as a Potential Biomarker of Alzheimer's DiseaseR01AG061138 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2019 to 2023
$3.6M
PET System for Preclinical ResearchS10OD016245 · OD · VANDERBILT UNIVERSITY · PI PETERSON, TODD E · 2013 to 2013
$584k
NIA NIH HHS R01 AG061138NICHD NIH HHS P50 HD103537NIH HHS S10 OD016245
6 · The paper itself

Abstract

L-ergothioneine (ERGO) is a potent antioxidant with cytoprotective effects. To study ERGO biodistribution and detect oxidative stress in vivo, we report an efficient and reproducible preparation of [

Indexed as

Alzheimer DiseaseErgothioneineAnimalsEstersOxidative StressPositron-Emission TomographyTissue DistributionErgothioneineEstersalzheimerergothioneineinflammationoxidative stressPET imagingROS

Identifiers

PMID35100442
PMCPMC9167250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.