Evidence map›Paper›PMID 35100335›Full record

ArticleG3 (Bethesda, Md.)2022

Drosophila centrocortin is dispensable for centriole duplication but contributes to centrosome separation.

Dipen S Mehta, Hala Zein-Sabatto, Pearl V Ryder, Jina Lee, Dorothy A Lerit

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dipen S MehtaCollege of Science and Mathematics, Augusta University, Augusta, GA 30912, USA.
Hala Zein-SabattoDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-8911-2759
Pearl V RyderDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0003-3699-3633
Jina LeeEmory College of Arts and Sciences, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-4362-9998
Dorothy A LeritDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-3362-8078
Emory University · USAugusta University · US

Funding

IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Post-transcriptional mechanisms of centrosome regulationR01GM138544 · NIGMS · EMORY UNIVERSITY · PI LERIT, DOROTHY A · 2020 to 2024
$1.8M
Regulation of Centrosomes by Localized RNAF32GM128407 · NIGMS · EMORY UNIVERSITY · PI RYDER, PEARL VICTORIA · 2018 to 2019
$131k
NIGMS NIH HHS F32 GM128407NIGMS NIH HHS K12 GM000680NIGMS NIH HHS R01 GM138544NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation, although a role in centriole duplication was not closely examined. Through time-lapse recordings of rapid syncytial divisions, we monitored centriole duplication and the kinetics of centrosome separation in control vs cen null embryos. Our data suggest that although cen is dispensable for centriole duplication, it contributes to centrosome separation.

Indexed as

CentriolesDrosophilaAnimalsCentrosomeMitosisSpindle ApparatuscentrocortincentrosomemitosisRNA localization

Identifiers

PMID35100335
PMCPMC9210305
OpenAlexW4220744247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.