Evidence map›Paper›PMID 35100309›Full record

ArticlePloS one2022

Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs.

Chiara Ronchini, Sara Gandini, Sebastiano Pasqualato, Luca Mazzarella, Federica Facciotti, Marina Mapelli, IEO Covid Team, Gianmaria Frige', Rita Passerini, Luca Pase and 5 more

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chiara RonchiniClinical Genomics, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0003-3908-4021
Sara GandiniDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0002-1348-4548
Sebastiano PasqualatoDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0002-9038-7768
Luca MazzarellaDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Federica FacciottiDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Marina MapelliDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
IEO Covid Team
Gianmaria Frige'Clinical Genomics, European Institute of Oncology IRCCS, Milan, Italy.
Rita PasseriniDivision of Laboratory Medicine, European Institute of Oncology IRCCS, Milan, Italy.
Luca PaseOccupational Medicine, European Institute of Oncology IRCCS, Milan, Italy.
Silvio CapizziMedical Administration, CMO, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Fabrizio MastrilliMedical Administration, CMO, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Roberto OrecchiaScientific Directorate, European Institute of Oncology IRCCS, Milan, Italy.
Gioacchino NatoliDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Pier Giuseppe PelicciDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.

Indexed as

AdultAgedAged, 80 and overAntibodies, Anti-IdiotypicAntibodies, ViralCOVID-19COVID-19 VaccinesFemaleHumansImmunoglobulin GMaleMass VaccinationMiddle AgedSARS-CoV-2Time FactorsYoung AdultAntibodies, Anti-IdiotypicAntibodies, ViralCOVID-19 VaccinesImmunoglobulin G

Identifiers

PMID35100309
PMCPMC8803178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.