Evidence map›Paper›PMID 35100264›Full record

ArticlePLoS computational biology2022

Sparse connectivity for MAP inference in linear models using sister mitral cells.

Sina Tootoonian, Andreas T Schaefer, Peter E Latham

Abstract read
In one paragraph

Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sina TootoonianGatsby Computational Neuroscience Unit, University College London, London, United Kingdom.ORCID 0000-0002-3990-8724
Andreas T SchaeferSensory Circuits and Neurotechnology Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-4677-8788
Peter E LathamGatsby Computational Neuroscience Unit, University College London, London, United Kingdom.ORCID 0000-0001-8713-9328

Funding

Cancer Research UKMedical Research Council MR/T046090/1Wellcome Trust 110174/Z/15/ZWellcome Trust FC001153
6 · The paper itself

Abstract

Sensory processing is hard because the variables of interest are encoded in spike trains in a relatively complex way. A major goal in studies of sensory processing is to understand how the brain extracts those variables. Here we revisit a common encoding model in which variables are encoded linearly. Although there are typically more variables than neurons, this problem is still solvable because only a small number of variables appear at any one time (sparse prior). However, previous solutions require all-to-all connectivity, inconsistent with the sparse connectivity seen in the brain. Here we propose an algorithm that provably reaches the MAP (maximum a posteriori) inference solution, but does so using sparse connectivity. Our algorithm is inspired by the circuit of the mouse olfactory bulb, but our approach is general enough to apply to other modalities. In addition, it should be possible to extend it to nonlinear encoding models.

Indexed as

AlgorithmsAction PotentialsAnimalsMiceNonlinear DynamicsSensory Receptor Cells

Identifiers

PMID35100264
PMCPMC8830798

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.