ArticlePLoS genetics2022
Redundant neural circuits regulate olfactory integration.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- [From the [Formula: see text]Method to the [Formula: see text]Method: A More Rigorous Approach to Real-time Quantitative Polymerase Chain Reaction Data Analysis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Locusts employ neuronal sensory prioritization to reconcile two conflicting olfactory signals while aggregating.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- [Effect of DifferentSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning.Nature communications · 2025Article
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- Nervous system guides behavioral immunity inPeerJ · 2024Review
- Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.PloS one · 2024Article
- Characterizing Three Azides for Their Potential Use asmicroPublication biology · 2023Article
- Positive interaction between ASH and ASK sensory neurons accelerates nociception and inhibits behavioral adaptation.iScience · 2022Article
- Sex differences in decision-making: Identifying multisensory behavioral differences in males and hermaphrodites.microPublication biology · 2022Article
- The Conscious Nematode: Exploring Hallmarks of Minimal Phenomenal Consciousness inInternational journal of psychological researchArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Olfactory integration is important for survival in a natural habitat. However, how the nervous system processes signals of two odorants present simultaneously to generate a coherent behavioral response is poorly understood. Here, we characterize circuit basis for a form of olfactory integration in Caenorhabditis elegans. We find that the presence of a repulsive odorant, 2-nonanone, that signals threat strongly blocks the attraction of other odorants, such as isoamyl alcohol (IAA) or benzaldehyde, that signal food. Using a forward genetic screen, we found that genes known to regulate the structure and function of sensory neurons, osm-5 and osm-1, played a critical role in the integration process. Loss of these genes mildly reduces the response to the repellent 2-nonanone and disrupts the integration effect. Restoring the function of OSM-5 in either AWB or ASH, two sensory neurons known to mediate 2-nonanone-evoked avoidance, is sufficient to rescue. Sensory neurons AWB and downstream interneurons AVA, AIB, RIM that play critical roles in olfactory sensorimotor response are able to process signals generated by 2-nonanone or IAA or the mixture of the two odorants and contribute to the integration. Thus, our results identify redundant neural circuits that regulate the robust effect of a repulsive odorant to block responses to attractive odorants and uncover the neuronal and cellular basis for this complex olfactory task.
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