Evidence map›Paper›PMID 35100012›Full record

ArticleInfection and immunity2022

Coxiella burnetii Virulent Phase I and Avirulent Phase II Variants Differentially Manipulate Autophagy Pathway in Neutrophils.

Venkatesh Kumaresan, Juexin Wang, Wendy Zhang, Yan Zhang, Dong Xu, Guoquan Zhang

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. VirCliaEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  6. Article
  7. The role of autophagy in pancreatic diseases.Frontiers in pharmacology · 2024
    Review
  8. Article
  9. The intricate dance: host autophagy andFrontiers in microbiology · 2023
    Review
  10. Establishing the intracellular niche of obligate intracellular vacuolar pathogens.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Venkatesh KumaresanDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0003-1950-6231
Juexin WangDepartment of Electrical Engineering and Computer Science, University of Missourigrid.134936.agrid.418801.4-Columbia, Columbia, Missouri, USA.
Wendy ZhangDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, Texas, USA.
Yan ZhangDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, Texas, USA.
Dong XuDepartment of Electrical Engineering and Computer Science, University of Missourigrid.134936.agrid.418801.4-Columbia, Columbia, Missouri, USA.
Guoquan ZhangDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-7273-8755
The University of Texas at San Antonio · USUniversity of Missouri · US

Funding

Mimetic Peptides-Mediated Protection Against Coxiella burnetii InfectionR01AI134681 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI ZHANG, GUOQUAN · 2018 to 2021
$2.1M
IDENTIFY NOVEL NEUTRALIZATION-SENSITIVE EPITOPES OF COXIELLA BURNETIIR21AI141945 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI ZHANG, GUOQUAN · 2019 to 2020
$417k
Mechanisms of B-1 Cell-Mediated Immunity Against Coxiella burnetii InfectionR21AI149044 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI ZHANG, GUOQUAN · 2020 to 2021
$391k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI134681HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI141945HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI149044NIAID NIH HHS R01 AI134681NIAID NIH HHS R21 AI141945NIAID NIH HHS R21 AI149044
6 · The paper itself

Abstract

Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes Q fever in humans. The virulent C. burnetii Nine Mile phase I (NMI) strain causes disease in animal models, while the avirulent NM phase II (NMII) strain does not. In this study, we found that NMI infection induces severe splenomegaly and bacterial burden in the spleen in BALB/c mice, while NMII infection does not. A significantly higher number of CD11b

Indexed as

Coxiella burnetiiQ FeverAnimalsAutophagyMacrophagesMiceNeutrophilsautophagosomeautophagyCoxiella burnetiidifferential gene expressionglutathionemembrane traffickingneutrophilspathogenesisphosphatidylinositolPI3 kinaseRNA-seq

Identifiers

PMID35100012
PMCPMC8929353
OpenAlexW4210627207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.