Evidence map›Paper›PMID 35100010›Full record

ArticleInfection and immunity2022

Chlamydia Deficient in Plasmid-Encoded Glycoprotein 3 (pGP3) as an Attenuated Live Oral Vaccine.

Zengzi Zhou, Qi Tian, Luying Wang, Guangming Zhong

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pathogenic and Protective Roles of Neutrophils inPathogens (Basel, Switzerland) · 2025
    Review
  5. Frontiers in cellular and infection microbiology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Potential Therapeutic Candidates againstInternational journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Zengzi ZhouThe 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qi TianDepartment of Medical Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan, China.
Luying WangThe 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0001-7053-5009
Central South University · CNHunan Provincial Maternal and Child Health Hospital · CNThe University of Texas Health Science Center at San Antonio · US

Funding

MECHANISMS OF CHLAMYDIAL EVASION OF IMMUNE RECOGNATIONR01AI047997 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2000 to 2021
$6.9M
Chlamydial plasmid-dependent pathogenesisR01AI121989 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2016 to 2019
$1.9M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI04797NIAID NIH HHS R01 AI047997NIAID NIH HHS R01 AI121989
6 · The paper itself

Abstract

Despite the extensive efforts, there is still a lack of a licensed vaccine against Chlamydia trachomatis in humans. The mouse genital tract infection with Chlamydia muridarum has been used to both investigate chlamydial pathogenic mechanisms and evaluate vaccine candidates due to the C. muridarum

Indexed as

Chlamydia InfectionsChlamydia muridarumAnimalsDisease Models, AnimalGlycoproteinsHumansMicePlasmidsVaccines, AttenuatedGlycoproteinsVaccines, Attenuatedattenuated oral vaccineChlamydia muridarumlive attenuatedoral vaccinepGP3pGP3 deficiencyplasmidplasmid-freetransmucosal immunitytransmucosal protection

Identifiers

PMID35100010
PMCPMC8929356
OpenAlexW4210383836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.