Evidence map›Paper›PMID 35099968›Full record

ArticleJournal of the American Chemical Society2022

Supramolecular Reinforcement of a Large-Pore 2D Covalent Organic Framework.

Shashini D Diwakara, Whitney S Y Ong, Yalini H Wijesundara, Robert L Gearhart, Fabian C Herbert, Sarah G Fisher, Gregory T McCandless, Sampath B Alahakoon, Jeremiah J Gassensmith, Sheel C Dodani and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Highly ordered mesoporous TiONature communications · 2026
    Article
  2. Article
  3. Review
  4. Tubular Nanostructures from Large-Pore 2D Covalent Organic Frameworks.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Rapid Formation of Vinylene-Linked Covalent Organic Frameworks Promoted by Dipole Moment.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shashini D DiwakaraDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Whitney S Y OngDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0001-9821-9972
Yalini H WijesundaraDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Robert L GearhartDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Fabian C HerbertDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Sarah G FisherDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Gregory T McCandlessDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Sampath B AlahakoonInstitute of Combinatorial Advanced Research and Education, General Sir John Kotelawala Defence University, Kandawala Rd., Ratmalana 10390, Sri Lanka.
Jeremiah J GassensmithDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0001-6400-8106
Sheel C DodaniDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0003-0271-6080
Ronald A SmaldoneDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0003-4560-7079

Funding

Optical Imaging Tools for Elucidating the Roles of Anions and Anionic Modifications in Cellular SignalingR35GM128923 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Sheel Dodani · 2018 to 2026
$3.4M
NIGMS NIH HHS R35 GM128923
6 · The paper itself

Abstract

Two-dimensional covalent organic frameworks (2D-COFs) are a class of crystalline porous organic polymers that consist of covalently linked, two-dimensional sheets that can stack together through noncovalent interactions. Here we report the synthesis of a novel COF, called PyCOFamide, which has an experimentally observed pore size that is greater than 6 nm in diameter. This is among the largest pore size reported to date for a 2D-COF. PyCOFamide exhibits permanent porosity and high crystallinity as evidenced by the nitrogen adsorption, powder X-ray diffraction, and high-resolution transmission electron microscopy. We show that the pore size of PyCOFamide is large enough to accommodate fluorescent proteins such as Superfolder green fluorescent protein and mNeonGreen. This work demonstrates the utility of noncovalent structural reinforcement in 2D-COFs to produce larger and persistent pore sizes than previously possible.

Indexed as

AdsorptionGreen Fluorescent ProteinsHydrogen BondingMetal-Organic FrameworksPorosityGreen Fluorescent ProteinsMetal-Organic Frameworks

Identifiers

PMID35099968
PMCPMC9173749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.