Evidence map›Paper›PMID 35099803›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes.

Jennifer R Baker, Nicholas S O'Brien, Kate L Prichard, Phillip J Robinson, Adam McCluskey, Cecilia C Russell

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer R BakerChemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, Australia.
Nicholas S O'BrienChemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, Australia.
Kate L PrichardChemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, Australia.
Phillip J RobinsonCell Signaling Unit, Children's Medical Research Institute, The University of Sydney, Sydney, NSW, Australia.
Adam McCluskeyChemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, Australia.
Cecilia C RussellChemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, Australia. Cecilia.Russell@newcastle.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This protocol describes the chemical synthesis of the dynamin inhibitors Dynole 34-2 and Acrylo-Dyn 2-30, and their chemical scaffold matched partner inactive compounds. The chosen active and inactive paired compounds represent potent dynamin inhibitors and very closely related dynamin-inactive compounds, with the synthesis of three of the four compounds readily possible via a common intermediate. Combined with the assay data provided, this allows the interrogation of dynamin in vitro and potentially in vivo.

Indexed as

DynaminsEndocytosisCyanoacrylatesIndolesCyanoacrylatesDynaminsdynole 34-2IndolesAcrylo-DynChemical synthesisDynamin inhibitorsDynoleDynole-31-2Dynole 34-2EndocytosisMolecular probes

Identifiers

PMID35099803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.