SynthesisReproductive sciences (Thousand Oaks, Calif.)2022
The Impact of Oocyte Vitrification on Offspring: a Systematic Review.
Synthesis in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Elective Egg Freezing for Non-Medical Reasons (Scientific Impact Paper No. 63, 2026 Second Edition).BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Single-cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development.Clinical and translational medicine · 2026Article
- Female fertility preservation: 25 years of progress, expanding indications and future prospects.Human reproduction update · 2026Review
- Lycopene improves the developmental competence of vitrified-thawed oocytes by reestablishing redox balance and modulating Rock1 expression.Journal of assisted reproduction and genetics · 2025Article
- Improved clinical outcomes with a modified warming protocol in donor oocyte cycles.Journal of ovarian research · 2025Article
- Comparative Embryological Outcomes of Vitrified and Fresh Oocytes in Patients with Diminished Ovarian Reserve.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Breast cancer Treatment and Fertility Preservation: A Narrative Review of Impacts, Strategies and Ethical Considerations.Current oncology reports · 2024Review
- Similar pregnancy outcomes from fresh and frozen donor oocytes transferred to gestational carriers: a SART database analysis isolating the effects of oocyte vitrification.Journal of assisted reproduction and genetics · 2024Article
- Oocyte Cryopreservation in Women with Ovarian Endometriosis.Journal of clinical medicine · 2023Review
- Reply: Concerns regarding the study "Comparing the effects of a commercial and a prototype vitrification medium on meiotic spindle morphology and survival rate of mouse oocytes".JBRA assisted reproduction · 2023Article
- Detrimental effects of vitrification on integrin genes (α9 and β1) and in vitro fertilization in mouse oocytes.Molecular biology reports · 2023Article
- Fertility preservation in pediatric healthcare: a review.Frontiers in endocrinology · 2023Review
- Effects of oocyte vitrification on gene expression in the liver and kidney tissues of adult offspring.Journal of assisted reproduction and genetics · 2022Article
- "Double Frozen Transfer" Could Influence the Perinatal and Children's Growth: A Nested Case-Control Study of 6705 Live Birth Cycles.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oocyte vitrification is a widespread and well-established assisted reproduction technique that has enabled some patient groups to obtain clinical results equivalent to those using fresh oocytes. However, as the number of babies born from vitrified oocytes has increased, so has the discussion regarding the method's safety for the offspring. Cryogenic oocyte damage caused by chemical, mechanical, and thermal stress has raised concern. In this systematic review, we asked the question of whether oocyte vitrification impacts offspring health. From 2007 to 2021, 13 studies were included in the analysis. All studies were observational and presented neonatal outcomes. A total of 4,159 babies were analyzed. Data from these studies were used to assess the following outcomes: multiple pregnancies, cesarean section, gestational age at delivery, the number of live births, birth weight, Apgar scores, congenital anomalies, and baby health. The most extended follow-ups evaluated children until 1, 2, and 6 years of age. According to the evidence appraised in this systematic review, vitrification seems to be a safe method for oocyte cryopreservation and child health, at least in the short term. Nevertheless, there is an urgent need for additional long-term data results from big databases and also for randomized controlled trials to improve the levels of evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.