Evidence map›Paper›PMID 35099760›Full record

ArticleInternational journal of hematology2022

Clinical outcomes and screening for organ involvement in pediatric Langerhans cell histiocytosis in Thailand: multicenter study on behalf of the Thai Pediatric Oncology Group.

Chalinee Monsereenusorn, Kunanya Suwannaying, Piti Techavichit, Lalita Sathitsamitphong, Patcharee Komvilaisak, Piya Rujkijyanont, Panya Seksarn, Pimlak Charoenkwan, Samart Pakakasama

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Chalinee MonsereenusornDivision of Hematology-Oncology, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, 315 Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand. chalinee_monsereenusorn@pedpmk.org.ORCID http://orcid.org/0000-0001-7960-5667
Kunanya SuwannayingDivision of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID http://orcid.org/0000-0002-7517-1416
Piti TechavichitClinical Research for Holistic Management in Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.ORCID http://orcid.org/0000-0002-1888-1446
Lalita SathitsamitphongDepartment of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID http://orcid.org/0000-0003-4774-259X
Patcharee KomvilaisakDivision of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID http://orcid.org/0000-0002-4118-8957
Piya RujkijyanontDivision of Hematology-Oncology, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, 315 Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.ORCID http://orcid.org/0000-0002-5006-9810
Panya SeksarnClinical Research for Holistic Management in Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.ORCID http://orcid.org/0000-0002-3125-9918
Pimlak CharoenkwanDepartment of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID http://orcid.org/0000-0002-9123-9177
Samart PakakasamaDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand. samart.pak@mahidol.ac.th.ORCID http://orcid.org/0000-0001-8118-163X
Chiang Mai University · THChulalongkorn University · THKhon Kaen University · THPhramongkutklao Hospital · THMahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease across all age groups and is characterized by various degrees of severity and organ system involvement. A multi-institutional retrospective study of pediatric patients with LCH treated between 1999 and 2018 at five pediatric oncology centers was conducted to describe the clinical characteristics, prognostic factors, and outcomes of LCH and to validate screening tools for organ system involvement in pediatric LCH in Thailand. A total of 127 patients with a median age of 2.7 years were studied. The single-to-multisystem (MS) LCH ratio was 1:1. Forty-seven patients (71%) with MS-LCH had risk-organ involvement (RO +), whereas 19 (29%) patients had no risk-organ involvement (RO -). The 5-year overall and event-free survival rates were 91.3% and 73.6%, respectively, which were comparable to those in developed countries. Prognostic factors included age < 2 years, RO + MS-LCH, and number of RO + . Abnormal complete blood count was a highly sensitive indicator of bone marrow involvement. Plain radiography is an appropriate screening tool to detect bone involvement.

Indexed as

Histiocytosis, Langerhans-CellNeoplasmsChildChild, PreschoolHumansInfantProgression-Free SurvivalRetrospective StudiesThailandLangerhans cell histiocytosisOutcomesRisk organScreeningThailand

Identifiers

PMID35099760
OpenAlexW4210327060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.