ArticleInternational urology and nephrology2022
The effect of intraurethral hyaluronic acid on healing and fibrosis in rats with experimentally induced urethral trauma.
Article in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- A Novel Role of Hyaluronan and Its Membrane Receptors, CD44 and RHAMM, in Obesity-Related Kidney Pathology.Biomolecules · 2025Article
- Standardizing urethral stricture models in rats: a comprehensive study on histomorphologic and molecular approach.International urology and nephrology · 2024Article
- Elevated RHAMM as a biomarker for predicting diabetic kidney disease in patients with type 2 diabetes.Clinical kidney journal · 2024Article
- The effect of intraurethral heparin on inflammation and spongiofibrosis in a rat model of experimentally induced urethral trauma.International urology and nephrology · 2023Article
- Re: The effect of intraurethral hyaluronic acid on healing and fibrosis in rats with experimentally induced urethral trauma.International urology and nephrology · 2022Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the efficacy of hyaluronic acid (HA) application after urethral trauma for preventing spongiofibrosis and inflammation in the early period.
methodsA total of twenty-four rats were divided into 3 groups, with 8 rats in each. The urethra was traumatized with a 24 G needle sheath in all rats. Group 1 of rats were applied 0.9% saline solution twice a day, Group 2 were applied 0.9% saline solution and sodium HA 1% once a day, Group 3 were applied 1.0% HA twice a day. After 21 days, penectomy was performed in all rats. Inflammation, spongiofibrosis, hyperemia and edema in the urethra were investigated for each group.
resultsHistopathologic analysis revealed less fibrosis in both group 2 and group 3 compared to Group 1 (p = 0.004). There were no statistically significant differences among the groups in terms of inflammation, hyperemia, edema and congestion (p = 0.563, p = 0.069, p = 0.069, p = 0.068, respectively). Severe fibrosis was observed in 6 (75%) rats in Group 1, and in none of the rats of Group 2 or Group 3. With respect to spongiofibrosis compared to the control group, both Group 2 and Group 3 have statistically significant differences (p = 0.004). Moderate spongiofibrosis was observed in 5 (62.5%) rats in Group 2 and in 3 (37.5%) rats in Group 3. Statistically, there were no significant differences in respect of severity between Group 2 and Group 3 (p = 0.014).
conclusionIntraurethral HA application after urethral trauma can decrease spongiofibrosis.
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