ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Skin Autofluorescence, a Noninvasive Biomarker of Advanced Glycation End-products, Is Associated With Frailty: The Rotterdam Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Skin Autofluorescence as a Potential Adjunctive Marker for Cardiovascular Risk Assessment in Type 2 Diabetes: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Sit-up test for assessing impaired blood pressure regulation in community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2025Article
- The Use of Advanced Glycation End-Product Measurements to Predict Post-Operative Complications After Cardiac Surgery.Journal of clinical medicine · 2025Review
- Advanced Glycation End-Products and Metabolomics Are Independently Associated With Frailty: The Longitudinal Doetinchem Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Frailty in Cardiac Surgery-Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Advanced Glycation End Products and Mobility Decline: A Novel Perspective on Aging.Healthcare (Basel, Switzerland) · 2025Article
- Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan.Communications biology · 2024Article
- Skin autofluorescence and cause-specific mortality in a population-based cohort.Scientific reports · 2024Article
- Association Between Advanced Glycation End Products and Sarcopenia: The Mediating Role of Osteoporosis.The Journal of clinical endocrinology and metabolism · 2024Article
- Skin senescence-from basic research to clinical practice.Frontiers in medicine · 2024Review
- The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters.Life (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAccumulation of advanced glycation end-products (AGEs) in tissues has been linked to various age-related disease phenotypes. Therefore, we investigated the potential relationship between skin AGE accumulation and frailty.
methodsA cross-sectional analysis was performed on 2 521 participants from the Rotterdam Study. Skin AGEs were assessed as skin autofluorescence (SAF) using the AGE reader™. We used 2 approaches to define frailty. Fried's criteria, including weight loss, weakness, slow gait speed, exhaustion, and low physical activity, were used to define physical frailty (presence of ≥3 components) and prefrailty (presence of ≤2 components). Rockwood's concept, including 38 deficits from physical and psychosocial health domains, was used to calculate the frailty index (score 0-1). Multinomial logistic and multivariate linear regression were used with SAF as exposure and physical frailty (ordinal) and frailty index (continuous) as outcome adjusting for age, sex, diabetes, renal function, socioeconomic status, and smoking status.
resultsThe mean SAF was 2.39 ± 0.49 arbitrary units and the median age was 74.2 (14.0) years. Regarding physical frailty, 96 persons (4%) were frail and 1 221 (48%) were prefrail. Skin autofluorescence was associated with both being prefrail (odds ratio [95% confidence interval] = 1.29 [1.07-1.56]) and frail (1.87 [1.20-2.90]) compared with nonfrail. Regarding the frailty index, the median value was 0.14 (0.10-0.19) and higher SAF was also associated with a higher frailty index (coefficient, B = 0.017 (0.011-0.023]).
conclusionsHigher skin AGEs are associated with both physical frailty and frailty index. Longitudinal studies are needed to evaluate the causality and the potential of SAF as a biomarker to screen frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.