ReviewThe Journal of endocrinology2022
The intestine and the microbiota in maternal glucose homeostasis during pregnancy.
Review in The Journal of endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women.Microbiology spectrum · 2024Trial
- Towards microbiome-informed strategies for predicting and preventing pregnancy complications.Reproduction & fertility · 2026Review
- Gut-placenta axis: gut microbiota metabolites may play a role in regulating maternal-fetal immune tolerance and the pathogenesis of adverse pregnancy outcomes.Frontiers in immunology · 2026Review
- Evaluation of standardized ileal digestibility of amino acids in corn, barley, wheat bran fed to primiparous sows during gestation, lactation, and post-weaning period.Journal of animal science · 2025Article
- Host-gut microbiota interactions during pregnancy.Evolution, medicine, and public health · 2024Review
- Parity modulates impact of BMI and gestational weight gain on gut microbiota in human pregnancy.Gut microbes · 2023Article
- Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations.Acta diabetologica · 2023Article
- Standardized ileal digestibility of amino acids in extruded full-fat soybean fed to non-gestating, gestating, and lactating sows.Journal of animal science · 2023Article
- Standardized ileal digestibility of amino acids in cottonseed meal fed to pregnant and non-pregnant sows.Journal of animal science · 2023Article
- Recurrent implantation failure: A comprehensive summary from etiology to treatment.Frontiers in endocrinology · 2022Review
- Distribution of Vaginal and Gut Microbiome in Advanced Maternal Age.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now well established that, beyond its role in nutrient processing and absorption, the intestine and its accompanying gut microbiome constitute a major site of immunological and endocrine regulation that mediates whole-body metabolism. Despite the growing field of host-microbe research, few studies explore what mechanisms govern this relationship in the context of pregnancy. During pregnancy, significant maternal metabolic adaptations are made to accommodate the additional energy demands of the developing fetus and to prevent adverse pregnancy outcomes. Recent data suggest that the maternal gut microbiota may play a role in these adaptations, but changes to maternal gut physiology and the underlying intestinal mechanisms remain unclear. In this review, we discuss selective aspects of intestinal physiology including the role of the incretin hormone, glucagon-like peptide 1 (GLP-1), and the role of the maternal gut microbiome in the maternal metabolic adaptations to pregnancy. Specifically, we discuss how bacterial components and metabolites could mediate the effects of the microbiota on host physiology, including nutrient absorption and GLP-1 secretion and action, and whether these mechanisms may change maternal insulin sensitivity and secretion during pregnancy. Finally, we discuss how these pathways could be altered in disease states during pregnancy including maternal obesity and diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.