ArticleJournal of medical Internet research2022
Ethical Issues of Digital Twins for Personalized Health Care Service: Preliminary Mapping Study.
Article in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Applications of digital twin technology in cardiometabolic disease management: a scoping review.BMC medical informatics and decision making · 2026Article
- Enhancing the resilience of remote patient monitoring and hospital-at-home systems: a digital-twin-based framework.npj health systems · 2026Review
- AI-driven big data analysis and predictive modeling of infectious disease immunity: from correlates to causal, multiscale understanding.Archives of microbiology · 2026Review
- Digital twins and digital models of the human circulatory system.Nature reviews bioengineering · 2026Article
- Digital Twin Technology In Radiology.Journal of imaging informatics in medicine · 2026Review
- Realising the digital twin: a thematic review and analysis of the ethical, legal, and social issues for digital twins in healthcare.AI & society · 2026Article
- A survey on ethical digital twins in healthcare.Frontiers in artificial intelligence · 2026Review
- AI-driven virtual cell models in preclinical research: technical pathways, validation mechanisms, and clinical translation potential.NPJ digital medicine · 2025Review
- Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective.Seminars in liver disease · 2025Review
- The ethical aspects of human organ-on-chip models: A mapping review.Stem cell reports · 2025Review
- Perspectives and Preferences on Developing a Digital Human System for Intrinsic Capacity Monitoring Underpinned by World Health Organization's Integrated Care for Older People Guideline: Qualitative Study.Journal of medical Internet research · 2025Article
- Enhancing randomized clinical trials with digital twins.NPJ systems biology and applications · 2025Review
- Digital Cognitive Twins in mental health.Nature. Mental health · 2025Article
- Digital twins for the era of personalized surgery.NPJ digital medicine · 2025Review
- Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Digital twins, synthetic patient data, and in-silico trials: can they empower paediatric clinical trials?The Lancet. Digital health · 2025Review
- Could digital twins be the next revolution in healthcare?European journal of public health · 2025Review
- Digital twin assisted surgery, concept, opportunities, and challenges.NPJ digital medicine · 2025Review
- The Era of Preemptive Medicine: Developing Medical Digital Twins through Omics, IoT, and AI Integration.JMA journal · 2025Review
- Medical Digital Twin: A Review on Technical Principles and Clinical Applications.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe concept of digital twins has great potential for transforming the existing health care system by making it more personalized. As a convergence of health care, artificial intelligence, and information and communication technologies, personalized health care services that are developed under the concept of digital twins raise a myriad of ethical issues. Although some of the ethical issues are known to researchers working on digital health and personalized medicine, currently, there is no comprehensive review that maps the major ethical risks of digital twins for personalized health care services.
objectiveThis study aims to fill the research gap by identifying the major ethical risks of digital twins for personalized health care services. We first propose a working definition for digital twins for personalized health care services to facilitate future discussions on the ethical issues related to these emerging digital health services. We then develop a process-oriented ethical map to identify the major ethical risks in each of the different data processing phases.
methodsWe resorted to the literature on eHealth, personalized medicine, precision medicine, and information engineering to identify potential issues and developed a process-oriented ethical map to structure the inquiry in a more systematic way. The ethical map allows us to see how each of the major ethical concerns emerges during the process of transforming raw data into valuable information. Developers of a digital twin for personalized health care service may use this map to identify ethical risks during the development stage in a more systematic way and can proactively address them.
resultsThis paper provides a working definition of digital twins for personalized health care services by identifying 3 features that distinguish the new application from other eHealth services. On the basis of the working definition, this paper further layouts 10 major operational problems and the corresponding ethical risks.
conclusionsIt is challenging to address all the major ethical risks that a digital twin for a personalized health care service might encounter proactively without a conceptual map at hand. The process-oriented ethical map we propose here can assist the developers of digital twins for personalized health care services in analyzing ethical risks in a more systematic manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.