Evidence map›Paper›PMID 35099217›Full record

ArticlePsychological trauma : theory, research, practice and policy2023

A longitudinal mediational investigation of risk pathways among cannabis use, interpersonal trauma exposure, and trauma-related distress.

Terrell A Hicks, Kaitlin E Bountress, Amy E Adkins, Dace S Svikis, Nathan A Gillespie, Danielle M Dick, Spit For Science Working Group, Ananda B Amstadter

Abstract read
In one paragraph

Article in Psychological trauma : theory, research, practice and policy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Terrell A HicksVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University.ORCID 0000-0001-8116-3677
Kaitlin E BountressVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University.
Amy E AdkinsDepartment of Psychology, Virginia Commonwealth University.ORCID 0000-0002-3576-3759
Dace S SvikisDepartment of Psychology, Virginia Commonwealth University.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University.
Danielle M DickDepartment of Psychology, Virginia Commonwealth University.
Spit For Science Working GroupDepartment of Psychology, Virginia Commonwealth University.
Ananda B AmstadterVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University.

Funding

Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI FAGAN, PEBBLES · 2018 to 2022
$20.8M
Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031990 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI CLORE, JOHN N. · 2010 to 2011
$7.7M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
An Alcohol Affected Sib Pair Study of Alcohol DependenceR37AA011408 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN · 2007 to 2016
$6.5M
Project 3: Cross Species Characterization of Gene Networks in Acute ResponsesP20AA017828 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI ZHAO, ZHONGMING · 2009 to 2012
$2.2M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Alcohol Use Phenotypes and Posttraumatic Stress Disorder: Investigating Shared Genetic, Behavioral, and Psychophysiological Risk FactorsK01AA028058 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOUNTRESS, KAITLIN ELIZABETH · 2020 to 2024
$876k
Genetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741k
Stress-induced drinking in Returning Soldiers: Genetic and Epigenetic MechanismsK02AA023239 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2014 to 2018
$643k
Genetics of Cannabis use and Trauma-related phenotypesF31DA048559 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HICKS, TERRELL ALEXANDER · 2020 to 2022
$96k
NCRR NIH HHS UL1 RR031990NIAAA NIH HHS K01 AA024152NIAAA NIH HHS K01 AA028058NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02 AA023239NIAAA NIH HHS P20 AA017828NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R37 AA011408NIDA NIH HHS F31 DA048559NIDA NIH HHS U54 DA036105NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

objectiveCollege students are at high risk for cannabis use, interpersonal trauma (IPT) exposure, and trauma-related distress (TRD). Two phenotypic etiologic models posited to explain associations between cannabis use and trauma-related phenotypes are the self-medication (trauma/TRD → cannabis use) and high-risk (cannabis use → trauma/TRD) hypotheses. The primary objective of the present study was to investigate direct and indirect associations among cannabis use, IPT exposure, and TRD above and beyond established covariates.

methodThe current study used data from the first assessment (i.e., baseline survey at Year 1 Fall) and two follow-up assessments (i.e., Year 1 Spring and Year 2 Spring) from an ongoing longitudinal study on college behavioral health. Participants were 4 cohorts of college students (

resultsResults suggest that more IPT exposure increases risk for TRD and subsequent nonexperimental (use 6+ times) cannabis use, and that experimental (use 1-5 times) and nonexperimental cannabis use increases risk for IPT exposure and subsequent TRD.

conclusionsBoth the self-medication and high-risk hypotheses were supported. Findings support a bidirectional causal relationship between cannabis use and trauma-related phenotypes. Additionally, results highlight areas for colleges to intervene among students to help reduce cannabis use and create a safer environment. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Indexed as

CannabisSubstance-Related DisordersEthanolHumansLongitudinal StudiesStudentsEthanol

Identifiers

PMID35099217
PMCPMC9339011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.