ArticleeLife2022
m6A modifications regulate intestinal immunity and rotavirus infection.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 48 citations in OpenAlex.
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- m6A epigenetic modification of viral RNA is critical for the transmission cycle of mosquito-borne flaviviruses.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- m6A RNA methylation modulates antiviral response in celiac disease.Genes and immunity · 2026Article
- Landscape of NFrontiers in microbiology · 2026Article
- mFrontiers in immunology · 2026Review
- DDX54 drives ALKBH5-mediated demethylation of selected transcripts to suppress interferon antiviral response.Journal of virology · 2025Article
- The role of mCell & bioscience · 2025Article
- RNA mCell investigation · 2025Article
- Phase transition of WTAP regulates meLife · 2025Article
- M6A Demethylase ALKBH5 in Human Diseases: From Structure to Mechanisms.Biomolecules · 2025Review
- Epigenetics in neonatal necrotizing enterocolitis: current understanding and the potential involvement of m6A modification.Frontiers in pediatrics · 2025Review
- Role of N6-Methyladenosine (m6A) epitranscriptomic mark in regulating viral infections and target for antiviral development.Frontiers in pharmacology · 2025Review
- Methyltransferase-like 3-mediated RNA NFrontiers in immunology · 2025Review
- Antiretroviral Therapy Suppresses RNAAIDS research and human retroviruses · 2024Article
- Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- RNA mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA.Journal of virology · 2024Article
- N6-methyladenosine modification positively regulate Japanese encephalitis virus replication.Virology journal · 2024Article
- Modifying the antiviral innate immune response by selective writing, erasing, and reading of mCell chemical biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
N6-methyladenosine (m6A) is an abundant mRNA modification and affects many biological processes. However, how m6A levels are regulated during physiological or pathological processes such as virus infections, and the in vivo function of m6A in the intestinal immune defense against virus infections are largely unknown. Here, we uncover a novel antiviral function of m6A modification during rotavirus (RV) infection in small bowel intestinal epithelial cells (IECs). We found that rotavirus infection induced global m6A modifications on mRNA transcripts by down-regulating the m6a eraser ALKBH5. Mice lacking the m6A writer enzymes METTL3 in IECs (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.