ArticlePsychological medicine2023
Differences in genetic risk score profiles for drug use disorder, major depression, and ADHD as a function of sex, age at onset, recurrence, mode of ascertainment, and treatment.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 36 citations in OpenAlex.
- Network analysis of the genetic relationships between twenty psychiatric and substance use disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Predicting the geographical distribution of drug use disorder in Sweden from the geographical variation in social deprivation, genetic risk and urbanization.Molecular psychiatry · 2026Article
- The typology of common psychiatric disorders as depicted by genetic maps: a study based on Swedish population-based registers.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Familial genetic risk for posttraumatic stress disorder: Associations with clinical features.Journal of traumatic stress · 2026Article
- The relationship in women between genetic liability and the risk of onset of alcohol use disorder while pregnant or rearing an infant, toddler, or preschool child.Molecular psychiatry · 2026Article
- The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.American journal of human genetics · 2026Article
- The Impact of a Registry-Based Environmental Risk Score on Episodes of Alcohol Use Disorder and Drug Use Disorder in Swedish National Samples.Journal of studies on alcohol and drugs · 2026Article
- Exploring the implications of case selection methods for psychiatric molecular genetic studies.Molecular psychiatry · 2025Article
- Profiles of Genetic Risks for Psychotic Disorders.JAMA psychiatry · 2025Article
- The moderation of genetic risk for ten major psychiatric and substance use disorders by the genetic aptitude for educational attainment.Molecular psychiatry · 2025Article
- The Prediction of Diagnostic Change From Bipolar Disorder to Schizophrenia and Schizophrenia to Bipolar Disorder in a Population-Based, Longitudinal, National Swedish Sample.Schizophrenia bulletin · 2025Article
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- The development of an environmental risk score using Swedish National Registers and its impact on subsequent episodes of major depression.Psychological medicine · 2025Article
- The familial aggregation and co-aggregation of drug use disorder and alcohol use disorder in siblings of affected individuals born 1950-1990: A birth cohort exposed to rising rates of drug use disorder.Psychological medicine · 2025Article
- The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity.Molecular psychiatry · 2025Article
- The risks for major psychiatric disorders in the siblings of probands with major depressive disorder.Molecular psychiatry · 2025Article
- The impact of family-genetic risk scores on social functioning in individuals affected with six major psychiatric and substance use disorders in a Swedish National Sample.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression.American journal of human genetics · 2024Article
- The geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation.Psychological medicine · 2024Article
- Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders.Psychological medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDo genetic risk profiles for drug use disorder (DUD), major depression (MD), and attention-deficit hyperactivity disorder (ADHD) differ substantially as a function of sex, age at onset (AAO), recurrence, mode of ascertainment, and treatment?
methodsFamily genetic risk scores (FGRS) for MD, anxiety disorders, bipolar disorder, schizophrenia, alcohol use disorder, DUD, ADHD, and autism-spectrum disorder were calculated from 1st-5th degree relatives in the Swedish population born 1932-1995 (
resultsDifferences in FGRS profiles for DUD, MD, and ADHD by sex were modest, but they varied substantially by AAO, recurrence, ascertainment, and treatment with scores typically higher in cases with greater severity (e.g. early AAO, high recurrence, ascertainment in high intensity clinical settings, and treatment). However, severity was not always related to purer genetic profiles, as genetic risk for many disorders often increased together. However, some results, such as by mode of ascertainment from different Swedish registries, produced qualitative differences in FGRS profiles.
conclusionsDifferences in FGRS profiles for DUD, MD, and ADHD varied substantially by AAO, recurrence, ascertainment, and treatment. Replication of psychiatric studies, particularly those examining genetic factors, may be difficult unless cases are matched not only by diagnosis but by important clinical characteristics. Genetic correlations between psychiatric disorders could arise through one disorder impacting on the patterns of ascertainment for the other, rather than from the direct effects of shared genetic liabilities.
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