Evidence map›Paper›PMID 35098491›Full record

ArticleInternal and emergency medicine2022

Prevalence of symptoms in 1512 COVID-19 patients: have dizziness and vertigo been underestimated thus far?

Mirko Aldè, Stefania Barozzi, Federica Di Berardino, Gianvincenzo Zuccotti, Dario Consonni, Umberto Ambrosetti, Marina Socci, Simona Bertoli, Alberto Battezzati, Andrea Foppiani and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Internal and emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mirko AldèDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy. mirko.alde@unimi.it.ORCID http://orcid.org/0000-0002-5511-8511
Stefania BarozziDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-4574-2193
Federica Di BerardinoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0001-7514-5624
Gianvincenzo ZuccottiDepartment of Pediatrics, Children's Hospital "Vittore Buzzi", Azienda Socio Sanitaria Territoriale (ASST) Fatebenefratelli, Milan, Italy.ORCID http://orcid.org/0000-0002-2795-9874
Dario ConsonniEpidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-8935-3843
Umberto AmbrosettiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-4445-910X
Marina SocciAudiology Unit, Department of Specialist Surgical Sciences, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.
Simona BertoliDepartment of Food Environmental and Nutritional Sciences (DeFENS), International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0001-5867-8074
Alberto BattezzatiDepartment of Food Environmental and Nutritional Sciences (DeFENS), International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-4134-0557
Andrea FoppianiDepartment of Food Environmental and Nutritional Sciences (DeFENS), International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-2803-7713
Diego ZanettiAudiology Unit, Department of Specialist Surgical Sciences, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.ORCID http://orcid.org/0000-0002-8116-4108
Lorenzo PignataroDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-1619-5124
Giovanna CantarellaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0001-6008-3010
University of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between SARS-CoV-2 infection and dizziness is still unclear. The aim of this study is to assess the prevalence and characteristics of dizziness and vertigo among patients with mild-to-moderate COVID-19. Patients discharged from the emergency rooms with a confirmed SARS-CoV-2 diagnosis were assisted by daily telephone calls until nasopharyngeal swab negativization, and specific symptoms concerning balance disorders were investigated through targeted questions posed by experienced physicians. The study included 1512 subjects (765 females, 747 males), with a median age of 51 ± 18.4 years. New-onset dizziness was reported by 251 (16.6%) patients, among whom 110 (43.8%) complained of lightheadedness, 70 (27.9%) of disequilibrium, 41 (16.3%) of presyncope, and 30 (12%) of vertigo. This study analyzed in detail the prevalence and pathophysiological mechanisms of the different types of balance disorders in a large sample, and the results suggest that dizziness should be included among the main symptoms of COVID-19 because one-sixth of patients reported this symptom, with females being significantly more affected than males (20.3 vs 12.9%, P < 0.001). Most cases of dizziness were attributable to lightheadedness, which was probably exacerbated by psychophysical stress following acute infection and mandatory quarantine. Vertigo should not be underestimated because it might underlie serious vestibular disorders, and disequilibrium in elderly individuals should be monitored due to the possible risk of falls.

Indexed as

COVID-19DizzinessAdultAgedCOVID-19 TestingFemaleHumansMaleMiddle AgedPrevalenceSARS-CoV-2VertigoBalance DisordersCOVID-19DizzinessPresyncopeSARS-CoV-2Vertigo

Identifiers

PMID35098491
PMCPMC8801188
OpenAlexW4210393690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.