Evidence map›Paper›PMID 35098396›Full record

ArticleMolecular biology reports2022

Alpha-lipoic acid preconditioning plus ischemic postconditioning provides additional protection against myocardial reperfusion injury of diabetic rats: modulation of autophagy and mitochondrial function.

Behnaz Mokhtari, Mahdi Abdoli-Shadbad, Alireza Alihemmati, Aniseh Javadi, Reza Badalzadeh

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Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Behnaz MokhtariDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahdi Abdoli-ShadbadDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Alireza AlihemmatiMolecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Aniseh JavadiStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza BadalzadehMolecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. badalzadehr@tbzmed.ac.ir.ORCID http://orcid.org/0000-0002-8092-7820
Tabriz University of Medical Sciences · IR

Funding

national institute for medical research development (nimad) 957279
6 · The paper itself

Abstract

backgroundInvestigating the interaction of diabetes with ischemic postconditioning (IPostC)-associated cardioprotection in myocardial ischemia/reperfusion (I/R) damage is of great clinical importance. The present work was designed to determine the possible synergistic effects of alpha-lipoic acid (LA) preconditioning and IPostC on myocardial I/R damage in type-II diabetic rats through modulating autophagy, and the involvement of mitochondrial function.

methodsHigh-fat diet/low dose of streptozotocin-induced type-II diabetic model with duration of 12 weeks was used in this study. LA (100 mg/kg/day) was administered orally in diabetic rats for 5 weeks before I/R. Myocardial I/R was established on Langendorff apparatus through the ligation of left anterior descending coronary artery for 35 min, then reperfusion for 60 min. IPostC was carried out immediately at the beginning of the reperfusion. At the end of the experiment, myocardial infarct size (IS), autophagy markers at both gene and protein levels, and mitochondrial ROS production and membrane potential were assessed.

resultsCombined conditioning with LA and ischemia significantly decreased the IS of diabetic hearts (P < 0.05), however, single therapies had no significant effects. LA in combination with IPostC more significantly decreased LC3 and p62 mRNA levels (P < 0.01), and LC3II/LC3I and p62 protein levels (P < 0.01). Also, this combined therapy decreased mitochondrial ROS generation and membrane depolarization (P < 0.01).

conclusionsPretreatment with LA in diabetic rats notably restored cardioprotection by IPostC via modulating autophagy and restoring mitochondrial function. This combined conditioning might be an effective strategy to diminish I/R damage in diabetic hearts.

Indexed as

Diabetes Mellitus, ExperimentalIschemic PostconditioningIschemic Preconditioning, MyocardialMyocardial Reperfusion InjuryThioctic AcidAnimalsAutophagyMitochondriaRatsThioctic AcidAlpha-lipoic acidAutophagyDiabetic heartIschemia/reperfusion injuryIschemic postconditioningMitochondrial function

Identifiers

PMID35098396
OpenAlexW4210650676

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.